Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis

Jing Li,1,* Tao Zhang,2,* Qingmiao Shao3 1Department of Transplantation, The First Central Hospital of Tianjin, 2Department of Nephrology, The First Affiliated Hospital of Tianjin Chinese Medical University, 3Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, Peop...

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Autores principales:	Li J, Zhang T, Shao Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Restless legs syndrome Hemodialysis Cardiovascular events Mortality Meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/65135d7d634448208bd1d646fee89aa5
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spelling	oai:doaj.org-article:65135d7d634448208bd1d646fee89aa52021-12-02T07:07:50ZPrognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis1178-2021https://doaj.org/article/65135d7d634448208bd1d646fee89aa52017-06-01T00:00:00Zhttps://www.dovepress.com/prognostic-value-of-restless-legs-syndrome-in-hemodialysis-patients-a--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jing Li,1,* Tao Zhang,2,* Qingmiao Shao3 1Department of Transplantation, The First Central Hospital of Tianjin, 2Department of Nephrology, The First Affiliated Hospital of Tianjin Chinese Medical University, 3Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China *These authors contributed equally to this work Background: Previous studies have revealed that restless legs syndrome (RLS) not only is frequently prevalent in dialysis patients but also increases the risk of death in dialysis patients, especially in hemodialysis (HD) patients. However, inconsistent results also still exist, having attracted confusion and discussion. Owing to mixed and inconclusive results, we conducted to perform the comprehensive meta-analysis to evaluate the potential prognostic value of RLS in HD patients. Materials and methods: We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase and Web of Science) to identify relevant studies reporting on all-cause mortality and cardiovascular (CV) events in HD patients suffering from RLS. We searched the literature published up to December 5, 2016, or earlier. We used both fixed- and random-effects models to calculate the overall effect estimate. An I2>50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results: A total of four studies including 1,839 patients found that there was no significant association between RLS and all-cause mortality (hazard ratio [HR]: 1.649; 95% confidence interval [CI]: 0.778–3.496) and CV events (HR: 0.863; 95% CI: 0.600–1.127) in HD patients. Heterogeneity among the studies was observed for all-cause mortality (I2=80.7%, P=0.001). Conclusion: Our meta-analysis suggests that there was no significant effect of RLS on all-cause mortality and CV events in HD patients. Therefore, large-scale and well-designed studies are needed to validate the association between RLS and the risk of death in HD patients. Keywords: restless legs syndrome, hemodialysis, cardiovascular events, mortality, meta-analysisLi JZhang TShao QDove Medical PressarticleRestless legs syndromeHemodialysisCardiovascular eventsMortalityMeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1569-1574 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Restless legs syndrome Hemodialysis Cardiovascular events Mortality Meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Restless legs syndrome Hemodialysis Cardiovascular events Mortality Meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li J Zhang T Shao Q Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
description	Jing Li,1,* Tao Zhang,2,* Qingmiao Shao3 1Department of Transplantation, The First Central Hospital of Tianjin, 2Department of Nephrology, The First Affiliated Hospital of Tianjin Chinese Medical University, 3Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China *These authors contributed equally to this work Background: Previous studies have revealed that restless legs syndrome (RLS) not only is frequently prevalent in dialysis patients but also increases the risk of death in dialysis patients, especially in hemodialysis (HD) patients. However, inconsistent results also still exist, having attracted confusion and discussion. Owing to mixed and inconclusive results, we conducted to perform the comprehensive meta-analysis to evaluate the potential prognostic value of RLS in HD patients. Materials and methods: We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase and Web of Science) to identify relevant studies reporting on all-cause mortality and cardiovascular (CV) events in HD patients suffering from RLS. We searched the literature published up to December 5, 2016, or earlier. We used both fixed- and random-effects models to calculate the overall effect estimate. An I2>50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results: A total of four studies including 1,839 patients found that there was no significant association between RLS and all-cause mortality (hazard ratio [HR]: 1.649; 95% confidence interval [CI]: 0.778–3.496) and CV events (HR: 0.863; 95% CI: 0.600–1.127) in HD patients. Heterogeneity among the studies was observed for all-cause mortality (I2=80.7%, P=0.001). Conclusion: Our meta-analysis suggests that there was no significant effect of RLS on all-cause mortality and CV events in HD patients. Therefore, large-scale and well-designed studies are needed to validate the association between RLS and the risk of death in HD patients. Keywords: restless legs syndrome, hemodialysis, cardiovascular events, mortality, meta-analysis
format	article
author	Li J Zhang T Shao Q
author_facet	Li J Zhang T Shao Q
author_sort	Li J
title	Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
title_short	Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
title_full	Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
title_fullStr	Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
title_full_unstemmed	Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
title_sort	prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/65135d7d634448208bd1d646fee89aa5
work_keys_str_mv	AT lij prognosticvalueofrestlesslegssyndromeinhemodialysispatientsasystematicreviewandmetaanalysis AT zhangt prognosticvalueofrestlesslegssyndromeinhemodialysispatientsasystematicreviewandmetaanalysis AT shaoq prognosticvalueofrestlesslegssyndromeinhemodialysispatientsasystematicreviewandmetaanalysis
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Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis

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