Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients

Background: The purpose of this study was to evaluate whether a prior diagnosis of malignancy affected the assessment of parathyroid hormone (PTH) in hypercalcemic patients and whether the rate of this assessment changed over time. Methods: A retrospective cohort study was designed that included adu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael T Sheehan, Ya-Huei Li, Suhail A Doi, Adedayo A Onitilo
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/651dcd63b4e14eb3a4db0fc83cb4e88a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:651dcd63b4e14eb3a4db0fc83cb4e88a
record_format	dspace
spelling	oai:doaj.org-article:651dcd63b4e14eb3a4db0fc83cb4e88a2021-11-30T23:34:34ZFrequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients1179-551410.1177/11795514211059494https://doaj.org/article/651dcd63b4e14eb3a4db0fc83cb4e88a2021-11-01T00:00:00Zhttps://doi.org/10.1177/11795514211059494https://doaj.org/toc/1179-5514Background: The purpose of this study was to evaluate whether a prior diagnosis of malignancy affected the assessment of parathyroid hormone (PTH) in hypercalcemic patients and whether the rate of this assessment changed over time. Methods: A retrospective cohort study was designed that included adult patients with hypercalcemia with and without a history of malignancy between January 1, 2000 and December 31, 2019 in the Marshfield Clinic Health System (MCHS). The overall and annual rates of PTH assessment in each group was determined. In patients with a PTH assessment, duration of time and number of elevated serum calcium levels between the first documentation of hypercalcemia and the assessment of PTH were recorded, as was the degree of hypercalcemia. Results: Approximately a quarter (23%) of the patients in each group had a PTH assessment. The rate of PTH assessment initially increased over time but later declined significantly. Although a more severe degree of hypercalcemia predicted a greater probability of PTH assessment, the rate of assessment declined with all degrees of hypercalcemia in the last 5 years. While most patients who had a PTH assessed did so within a few months of the first documentation of hypercalcemia, less than half (40%) had a delay of more than 2 years before a PTH level was drawn. Conclusion: This lack of appropriate and timely assessment may have significant health consequences in both groups of patients. Better education of providers about the appropriate and timely assessment of PTH in the evaluation of hypercalcemia is urgently needed.Michael T SheehanYa-Huei LiSuhail A DoiAdedayo A OnitiloSAGE PublishingarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENClinical Medicine Insights: Endocrinology and Diabetes, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Michael T Sheehan Ya-Huei Li Suhail A Doi Adedayo A Onitilo Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
description	Background: The purpose of this study was to evaluate whether a prior diagnosis of malignancy affected the assessment of parathyroid hormone (PTH) in hypercalcemic patients and whether the rate of this assessment changed over time. Methods: A retrospective cohort study was designed that included adult patients with hypercalcemia with and without a history of malignancy between January 1, 2000 and December 31, 2019 in the Marshfield Clinic Health System (MCHS). The overall and annual rates of PTH assessment in each group was determined. In patients with a PTH assessment, duration of time and number of elevated serum calcium levels between the first documentation of hypercalcemia and the assessment of PTH were recorded, as was the degree of hypercalcemia. Results: Approximately a quarter (23%) of the patients in each group had a PTH assessment. The rate of PTH assessment initially increased over time but later declined significantly. Although a more severe degree of hypercalcemia predicted a greater probability of PTH assessment, the rate of assessment declined with all degrees of hypercalcemia in the last 5 years. While most patients who had a PTH assessed did so within a few months of the first documentation of hypercalcemia, less than half (40%) had a delay of more than 2 years before a PTH level was drawn. Conclusion: This lack of appropriate and timely assessment may have significant health consequences in both groups of patients. Better education of providers about the appropriate and timely assessment of PTH in the evaluation of hypercalcemia is urgently needed.
format	article
author	Michael T Sheehan Ya-Huei Li Suhail A Doi Adedayo A Onitilo
author_facet	Michael T Sheehan Ya-Huei Li Suhail A Doi Adedayo A Onitilo
author_sort	Michael T Sheehan
title	Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
title_short	Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
title_full	Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
title_fullStr	Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
title_full_unstemmed	Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
title_sort	frequency of parathyroid hormone assessment in the evaluation of hypercalcemia. a comparison between patients with and without a history of malignancy in a 20-year dataset of 20,954 patients
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/651dcd63b4e14eb3a4db0fc83cb4e88a
work_keys_str_mv	AT michaeltsheehan frequencyofparathyroidhormoneassessmentintheevaluationofhypercalcemiaacomparisonbetweenpatientswithandwithoutahistoryofmalignancyina20yeardatasetof20954patients AT yahueili frequencyofparathyroidhormoneassessmentintheevaluationofhypercalcemiaacomparisonbetweenpatientswithandwithoutahistoryofmalignancyina20yeardatasetof20954patients AT suhailadoi frequencyofparathyroidhormoneassessmentintheevaluationofhypercalcemiaacomparisonbetweenpatientswithandwithoutahistoryofmalignancyina20yeardatasetof20954patients AT adedayoaonitilo frequencyofparathyroidhormoneassessmentintheevaluationofhypercalcemiaacomparisonbetweenpatientswithandwithoutahistoryofmalignancyina20yeardatasetof20954patients
_version_	1718406204660645888

Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients

Ejemplares similares