Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

Abstract Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in comm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gang Huang, Junbo Xu, Tingjie Zhang, Lin Cai, Hanxiong Liu, Xiuqiong Yu, Jing Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6523ffb88de849388fa40a0491123d6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6523ffb88de849388fa40a0491123d6f
record_format	dspace
spelling	oai:doaj.org-article:6523ffb88de849388fa40a0491123d6f2021-12-02T14:47:32ZHyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu10.1038/s41598-020-65605-w2045-2322https://doaj.org/article/6523ffb88de849388fa40a0491123d6f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65605-whttps://doaj.org/toc/2045-2322Abstract Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.Gang HuangJunbo XuTingjie ZhangLin CaiHanxiong LiuXiuqiong YuJing WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gang Huang Junbo Xu Tingjie Zhang Lin Cai Hanxiong Liu Xiuqiong Yu Jing Wu Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
description	Abstract Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.
format	article
author	Gang Huang Junbo Xu Tingjie Zhang Lin Cai Hanxiong Liu Xiuqiong Yu Jing Wu
author_facet	Gang Huang Junbo Xu Tingjie Zhang Lin Cai Hanxiong Liu Xiuqiong Yu Jing Wu
author_sort	Gang Huang
title	Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_short	Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_full	Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_fullStr	Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_full_unstemmed	Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_sort	hyperuricemia is associated with metabolic syndrome in the community very elderly in chengdu
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6523ffb88de849388fa40a0491123d6f
work_keys_str_mv	AT ganghuang hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT junboxu hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT tingjiezhang hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT lincai hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT hanxiongliu hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT xiuqiongyu hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu AT jingwu hyperuricemiaisassociatedwithmetabolicsyndromeinthecommunityveryelderlyinchengdu
_version_	1718389512726380544

Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

Ejemplares similares