A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.

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Detalles Bibliográficos
Autores principales: Paul Murima, Michael Zimmermann, Tarun Chopra, Florence Pojer, Giulia Fonti, Matteo Dal Peraro, Sylvie Alonso, Uwe Sauer, Kevin Pethe, John D. McKinney
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/652596cd6de34172bdbad20c07b19e07
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Sumario:Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.