A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.

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Autores principales:	Paul Murima, Michael Zimmermann, Tarun Chopra, Florence Pojer, Giulia Fonti, Matteo Dal Peraro, Sylvie Alonso, Uwe Sauer, Kevin Pethe, John D. McKinney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/652596cd6de34172bdbad20c07b19e07
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spelling	oai:doaj.org-article:652596cd6de34172bdbad20c07b19e072021-12-02T14:39:35ZA rheostat mechanism governs the bifurcation of carbon flux in mycobacteria10.1038/ncomms125272041-1723https://doaj.org/article/652596cd6de34172bdbad20c07b19e072016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12527https://doaj.org/toc/2041-1723Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.Paul MurimaMichael ZimmermannTarun ChopraFlorence PojerGiulia FontiMatteo Dal PeraroSylvie AlonsoUwe SauerKevin PetheJohn D. McKinneyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul Murima Michael Zimmermann Tarun Chopra Florence Pojer Giulia Fonti Matteo Dal Peraro Sylvie Alonso Uwe Sauer Kevin Pethe John D. McKinney A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
description	Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.
format	article
author	Paul Murima Michael Zimmermann Tarun Chopra Florence Pojer Giulia Fonti Matteo Dal Peraro Sylvie Alonso Uwe Sauer Kevin Pethe John D. McKinney
author_facet	Paul Murima Michael Zimmermann Tarun Chopra Florence Pojer Giulia Fonti Matteo Dal Peraro Sylvie Alonso Uwe Sauer Kevin Pethe John D. McKinney
author_sort	Paul Murima
title	A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
title_short	A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
title_full	A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
title_fullStr	A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
title_full_unstemmed	A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
title_sort	rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/652596cd6de34172bdbad20c07b19e07
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A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

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