A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.

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Bibliographic Details
Main Authors: Paul Murima, Michael Zimmermann, Tarun Chopra, Florence Pojer, Giulia Fonti, Matteo Dal Peraro, Sylvie Alonso, Uwe Sauer, Kevin Pethe, John D. McKinney
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/652596cd6de34172bdbad20c07b19e07
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