Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the eff...

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Autores principales:	Niloufar Rasaei, Omid Asbaghi, Mahsa Samadi, Leila Setayesh, Reza Bagheri, Fatemeh Gholami, Neda Soveid, Krista Casazza, Alexei Wong, Katsuhiko Suzuki, Khadijeh Mirzaei
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	green tea oxidative stress total antioxidant capacity malondialdehyde Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6526a122bc89464082f0b6f3ee08489d
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spelling	oai:doaj.org-article:6526a122bc89464082f0b6f3ee08489d2021-11-25T16:27:23ZEffect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials10.3390/antiox101117312076-3921https://doaj.org/article/6526a122bc89464082f0b6f3ee08489d2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1731https://doaj.org/toc/2076-3921It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the effects of green tea supplementation on oxidative stress in adults. A systematic search of English language publications up to 21 August 2021 was carried out in PubMed, Scopus, Embase, and ISI Web of Science, utilizing pertinent keywords. These searches included randomized controlled trials (RCTs) evaluating the relationship between green tea supplementation, malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence intervals (95% CI). Meta-regression and non-linear dose-response analyses were performed to investigate the association between the dosage of green tea (mg/day) and the duration of the intervention (weeks) with pooled effect size. Sixteen RCTs with seventeen arms including 760 participants met the inclusion criteria. Our results indicated that green tea supplementation had significant effects on TAC (weighted mean difference [WMD]: 0.20 mmol/L; 95% CI: 0.09, 0.30, <i>p</i> < 0.001) and significant heterogeneity between studies (I<sup>2</sup> = 98.6%, <i>p</i> < 0.001), which was largely related to gender and body mass index (BMI). Subgroup analysis in TAC identified a significant relationship except with low dose supplementation and obese individuals. No relationship between MDA and green tea supplementation was observed in any subgroups; however, meta-regression analysis revealed a linear inverse association between the dosage and significant change in MDA (<i>r</i> = −2117.18, <i>p</i> = 0.017). Our outcomes suggest that green tea supplementation improves TAC and affects MDA based on the dose of the intervention in adults. Future RCTs with longer durations are needed to expand our findings.Niloufar RasaeiOmid AsbaghiMahsa SamadiLeila SetayeshReza BagheriFatemeh GholamiNeda SoveidKrista CasazzaAlexei WongKatsuhiko SuzukiKhadijeh MirzaeiMDPI AGarticlegreen teaoxidative stresstotal antioxidant capacitymalondialdehydeTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1731, p 1731 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	green tea oxidative stress total antioxidant capacity malondialdehyde Therapeutics. Pharmacology RM1-950
spellingShingle	green tea oxidative stress total antioxidant capacity malondialdehyde Therapeutics. Pharmacology RM1-950 Niloufar Rasaei Omid Asbaghi Mahsa Samadi Leila Setayesh Reza Bagheri Fatemeh Gholami Neda Soveid Krista Casazza Alexei Wong Katsuhiko Suzuki Khadijeh Mirzaei Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
description	It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the effects of green tea supplementation on oxidative stress in adults. A systematic search of English language publications up to 21 August 2021 was carried out in PubMed, Scopus, Embase, and ISI Web of Science, utilizing pertinent keywords. These searches included randomized controlled trials (RCTs) evaluating the relationship between green tea supplementation, malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence intervals (95% CI). Meta-regression and non-linear dose-response analyses were performed to investigate the association between the dosage of green tea (mg/day) and the duration of the intervention (weeks) with pooled effect size. Sixteen RCTs with seventeen arms including 760 participants met the inclusion criteria. Our results indicated that green tea supplementation had significant effects on TAC (weighted mean difference [WMD]: 0.20 mmol/L; 95% CI: 0.09, 0.30, <i>p</i> < 0.001) and significant heterogeneity between studies (I<sup>2</sup> = 98.6%, <i>p</i> < 0.001), which was largely related to gender and body mass index (BMI). Subgroup analysis in TAC identified a significant relationship except with low dose supplementation and obese individuals. No relationship between MDA and green tea supplementation was observed in any subgroups; however, meta-regression analysis revealed a linear inverse association between the dosage and significant change in MDA (<i>r</i> = −2117.18, <i>p</i> = 0.017). Our outcomes suggest that green tea supplementation improves TAC and affects MDA based on the dose of the intervention in adults. Future RCTs with longer durations are needed to expand our findings.
format	article
author	Niloufar Rasaei Omid Asbaghi Mahsa Samadi Leila Setayesh Reza Bagheri Fatemeh Gholami Neda Soveid Krista Casazza Alexei Wong Katsuhiko Suzuki Khadijeh Mirzaei
author_facet	Niloufar Rasaei Omid Asbaghi Mahsa Samadi Leila Setayesh Reza Bagheri Fatemeh Gholami Neda Soveid Krista Casazza Alexei Wong Katsuhiko Suzuki Khadijeh Mirzaei
author_sort	Niloufar Rasaei
title	Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
title_short	Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
title_full	Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
title_fullStr	Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
title_full_unstemmed	Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
title_sort	effect of green tea supplementation on antioxidant status in adults: a systematic review and meta-analysis of randomized clinical trials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6526a122bc89464082f0b6f3ee08489d
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Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

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