Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.

Provision of antiretroviral treatment (ART) to people living with HIV (PLWH) has increased globally. Research measuring whether ART restores subjective well-being to "normal" levels is lacking, particularly in resource limited settings. The study objectives are to compare quality of life a...

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Autores principales:	Faith Martin, Steve Russell, Janet Seeley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6528c2897d8b460798ab340c073e8918
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spelling	oai:doaj.org-article:6528c2897d8b460798ab340c073e89182021-11-25T06:02:44ZHigher quality of life and lower depression for people on ART in Uganda as compared to a community control group.1932-620310.1371/journal.pone.0105154https://doaj.org/article/6528c2897d8b460798ab340c073e89182014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25171340/?tool=EBIhttps://doaj.org/toc/1932-6203Provision of antiretroviral treatment (ART) to people living with HIV (PLWH) has increased globally. Research measuring whether ART restores subjective well-being to "normal" levels is lacking, particularly in resource limited settings. The study objectives are to compare quality of life and depression symptoms for PLWH on ART to a general community population and to explore factors to explain these differences, including socio-economic status and the impact of urban or rural residence. PLWH on ART (n = 263) were recruited from ART delivery sites and participants not on ART (n = 160) were recruited from communities in Wakiso District, Uganda. Participants were interviewed using the translated World Health Organisation Quality of Life brief measure, the Hopkins Symptom Checklist depression section, and questions about socio-economic status, residence as urban or rural and, for PLWH on ART, self-reported adherence and use of HIV counselling. Compared to the community sample and controlling for location of residence, PLWH on ART had significantly higher quality of life (QOL) for physical, psychological and environment domains, but not the social domain. These differences were not due to socio-economic status alone. Depression scores were significantly lower for PLWH on ART. Both comparisons controlled for the effect of location of residence. People on ART self-reported high adherence and the majority had used HIV counselling services. Our findings show better QOL amongst PLWH on ART compared to a general community sample, which cannot be explained solely by differences in socio-economic status nor location of residence. The general community sample results point towards the challenges of life in this setting. Access to health services may underpin this difference and further research should explore this finding, in addition to identification of psychological mechanisms that relate to better QOL. ART provision infrastructure has clear benefits. Further work should consider sustainability and replication for other health conditions.Faith MartinSteve RussellJanet SeeleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105154 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faith Martin Steve Russell Janet Seeley Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
description	Provision of antiretroviral treatment (ART) to people living with HIV (PLWH) has increased globally. Research measuring whether ART restores subjective well-being to "normal" levels is lacking, particularly in resource limited settings. The study objectives are to compare quality of life and depression symptoms for PLWH on ART to a general community population and to explore factors to explain these differences, including socio-economic status and the impact of urban or rural residence. PLWH on ART (n = 263) were recruited from ART delivery sites and participants not on ART (n = 160) were recruited from communities in Wakiso District, Uganda. Participants were interviewed using the translated World Health Organisation Quality of Life brief measure, the Hopkins Symptom Checklist depression section, and questions about socio-economic status, residence as urban or rural and, for PLWH on ART, self-reported adherence and use of HIV counselling. Compared to the community sample and controlling for location of residence, PLWH on ART had significantly higher quality of life (QOL) for physical, psychological and environment domains, but not the social domain. These differences were not due to socio-economic status alone. Depression scores were significantly lower for PLWH on ART. Both comparisons controlled for the effect of location of residence. People on ART self-reported high adherence and the majority had used HIV counselling services. Our findings show better QOL amongst PLWH on ART compared to a general community sample, which cannot be explained solely by differences in socio-economic status nor location of residence. The general community sample results point towards the challenges of life in this setting. Access to health services may underpin this difference and further research should explore this finding, in addition to identification of psychological mechanisms that relate to better QOL. ART provision infrastructure has clear benefits. Further work should consider sustainability and replication for other health conditions.
format	article
author	Faith Martin Steve Russell Janet Seeley
author_facet	Faith Martin Steve Russell Janet Seeley
author_sort	Faith Martin
title	Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
title_short	Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
title_full	Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
title_fullStr	Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
title_full_unstemmed	Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.
title_sort	higher quality of life and lower depression for people on art in uganda as compared to a community control group.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6528c2897d8b460798ab340c073e8918
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Higher quality of life and lower depression for people on ART in Uganda as compared to a community control group.

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