Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells....

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Autores principales:	Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica, Alberto Pascual
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe0
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spelling	oai:doaj.org-article:65297e3308ba45ef8cbc879a7f19dfe02021-12-02T15:00:58ZNon-productive angiogenesis disassembles Aß plaque-associated blood vessels10.1038/s41467-021-23337-z2041-1723https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23337-zhttps://doaj.org/toc/2041-1723Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells.Maria I. Alvarez-VergaraAlicia E. Rosales-NievesRosana March-DiazGuiomar Rodriguez-PerinanNieves Lara-UreñaClara Ortega-de San LuisManuel A. Sanchez-GarciaMiguel Martin-BornezPedro Gómez-GálvezPablo Vicente-MunueraBeatriz Fernandez-GomezMiguel A. MarchenaAndrea S. Bullones-BolanosJose C. DavilaRocio Gonzalez-MartinezJose L. Trillo-ContrerasAna C. Sanchez-HidalgoRaquel del ToroFrancisco G. SchollEloisa HerreraMartin TrepelJakob KörbelinLuis M. EscuderoJavier VilladiegoMiriam EchevarriaFernando de CastroAntonia GutierrezAlberto RabanoJavier VitoricaAlberto PascualNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria I. Alvarez-Vergara Alicia E. Rosales-Nieves Rosana March-Diaz Guiomar Rodriguez-Perinan Nieves Lara-Ureña Clara Ortega-de San Luis Manuel A. Sanchez-Garcia Miguel Martin-Bornez Pedro Gómez-Gálvez Pablo Vicente-Munuera Beatriz Fernandez-Gomez Miguel A. Marchena Andrea S. Bullones-Bolanos Jose C. Davila Rocio Gonzalez-Martinez Jose L. Trillo-Contreras Ana C. Sanchez-Hidalgo Raquel del Toro Francisco G. Scholl Eloisa Herrera Martin Trepel Jakob Körbelin Luis M. Escudero Javier Villadiego Miriam Echevarria Fernando de Castro Antonia Gutierrez Alberto Rabano Javier Vitorica Alberto Pascual Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
description	Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells.
format	article
author	Maria I. Alvarez-Vergara Alicia E. Rosales-Nieves Rosana March-Diaz Guiomar Rodriguez-Perinan Nieves Lara-Ureña Clara Ortega-de San Luis Manuel A. Sanchez-Garcia Miguel Martin-Bornez Pedro Gómez-Gálvez Pablo Vicente-Munuera Beatriz Fernandez-Gomez Miguel A. Marchena Andrea S. Bullones-Bolanos Jose C. Davila Rocio Gonzalez-Martinez Jose L. Trillo-Contreras Ana C. Sanchez-Hidalgo Raquel del Toro Francisco G. Scholl Eloisa Herrera Martin Trepel Jakob Körbelin Luis M. Escudero Javier Villadiego Miriam Echevarria Fernando de Castro Antonia Gutierrez Alberto Rabano Javier Vitorica Alberto Pascual
author_facet	Maria I. Alvarez-Vergara Alicia E. Rosales-Nieves Rosana March-Diaz Guiomar Rodriguez-Perinan Nieves Lara-Ureña Clara Ortega-de San Luis Manuel A. Sanchez-Garcia Miguel Martin-Bornez Pedro Gómez-Gálvez Pablo Vicente-Munuera Beatriz Fernandez-Gomez Miguel A. Marchena Andrea S. Bullones-Bolanos Jose C. Davila Rocio Gonzalez-Martinez Jose L. Trillo-Contreras Ana C. Sanchez-Hidalgo Raquel del Toro Francisco G. Scholl Eloisa Herrera Martin Trepel Jakob Körbelin Luis M. Escudero Javier Villadiego Miriam Echevarria Fernando de Castro Antonia Gutierrez Alberto Rabano Javier Vitorica Alberto Pascual
author_sort	Maria I. Alvarez-Vergara
title	Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
title_short	Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
title_full	Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
title_fullStr	Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
title_full_unstemmed	Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
title_sort	non-productive angiogenesis disassembles aß plaque-associated blood vessels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe0
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Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

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