Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells

Abstract Background Leukoreduction of blood products is commonly performed in human medicine, but its effect on outcome or incidence of transfusion reactions (TRs) in dogs is unknown. Objectives To prospectively evaluate the incidence of acute TRs in, and the outcome of, dogs receiving either leukor...

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Autores principales:	Sinziana Maria Radulescu, Ragnhild Skulberg, Charlotte McDonald, Daniel L. Chan, Karen Humm
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	anemia febrile non‐hemolytic transfusion reactions Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/6531b4ff04b24080a7d2262f5dfae04b
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spelling	oai:doaj.org-article:6531b4ff04b24080a7d2262f5dfae04b2021-11-30T17:01:03ZRandomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells1939-16760891-664010.1111/jvim.16138https://doaj.org/article/6531b4ff04b24080a7d2262f5dfae04b2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16138https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Leukoreduction of blood products is commonly performed in human medicine, but its effect on outcome or incidence of transfusion reactions (TRs) in dogs is unknown. Objectives To prospectively evaluate the incidence of acute TRs in, and the outcome of, dogs receiving either leukoreduced (LR) or nonleukoreduced (N‐LR) packed red blood cells (PRBC). Animals Dogs (n = 194) administered PRBC between August 2017 and June 2020. Methods Prospective randomized double‐blinded clinical trial. Dogs were randomized to receive either LR or N‐LR PRBC and clinicians, nurses and investigators were blinded to the group allocations. The incidence of TRs, change in PCV, hospitalization duration, and survival to discharge were recorded. Results Out of the 194 dogs, 96 received LR and 98 received N‐LR PRBCs. The mean 12‐hour change in PCV value was +9.22% (SD 5.27%) for dogs that received N‐LR and +10.69% (SD 6.44%) for dogs that received LR PRBC (effect size 0.26, 95% confidence interval [CI] −0.02 to 0.55), which was not significantly different (P = .08). TRs were documented in 16/194 (8.24%) dogs, with 1/194 (0.51%) being a mild allergic reaction, while 15/194 (7.73%) had suspected febrile nonhemolytic TRs (FNHTRs). FNHTR incidence was not significantly different between the LR (6/96, 6.25%, 95% CI 2.8‐13.56) and N‐LR (9/98, 9.18%, 95% CI 4.92‐17.11) groups (P = .81). Of the 156 dogs that survived to discharge, 80/156 received N‐LR PRBC and 76/156 received LR PRBC which was not significantly different (P = .66). Conclusions and Clinical Importance A clinical advantage of using LR over N‐LR PRBC in terms of TRs and increase in PCV after transfusion was not detected.Sinziana Maria RadulescuRagnhild SkulbergCharlotte McDonaldDaniel L. ChanKaren HummWileyarticleanemiafebrile non‐hemolytic transfusion reactionsVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1325-1332 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia febrile non‐hemolytic transfusion reactions Veterinary medicine SF600-1100
spellingShingle	anemia febrile non‐hemolytic transfusion reactions Veterinary medicine SF600-1100 Sinziana Maria Radulescu Ragnhild Skulberg Charlotte McDonald Daniel L. Chan Karen Humm Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
description	Abstract Background Leukoreduction of blood products is commonly performed in human medicine, but its effect on outcome or incidence of transfusion reactions (TRs) in dogs is unknown. Objectives To prospectively evaluate the incidence of acute TRs in, and the outcome of, dogs receiving either leukoreduced (LR) or nonleukoreduced (N‐LR) packed red blood cells (PRBC). Animals Dogs (n = 194) administered PRBC between August 2017 and June 2020. Methods Prospective randomized double‐blinded clinical trial. Dogs were randomized to receive either LR or N‐LR PRBC and clinicians, nurses and investigators were blinded to the group allocations. The incidence of TRs, change in PCV, hospitalization duration, and survival to discharge were recorded. Results Out of the 194 dogs, 96 received LR and 98 received N‐LR PRBCs. The mean 12‐hour change in PCV value was +9.22% (SD 5.27%) for dogs that received N‐LR and +10.69% (SD 6.44%) for dogs that received LR PRBC (effect size 0.26, 95% confidence interval [CI] −0.02 to 0.55), which was not significantly different (P = .08). TRs were documented in 16/194 (8.24%) dogs, with 1/194 (0.51%) being a mild allergic reaction, while 15/194 (7.73%) had suspected febrile nonhemolytic TRs (FNHTRs). FNHTR incidence was not significantly different between the LR (6/96, 6.25%, 95% CI 2.8‐13.56) and N‐LR (9/98, 9.18%, 95% CI 4.92‐17.11) groups (P = .81). Of the 156 dogs that survived to discharge, 80/156 received N‐LR PRBC and 76/156 received LR PRBC which was not significantly different (P = .66). Conclusions and Clinical Importance A clinical advantage of using LR over N‐LR PRBC in terms of TRs and increase in PCV after transfusion was not detected.
format	article
author	Sinziana Maria Radulescu Ragnhild Skulberg Charlotte McDonald Daniel L. Chan Karen Humm
author_facet	Sinziana Maria Radulescu Ragnhild Skulberg Charlotte McDonald Daniel L. Chan Karen Humm
author_sort	Sinziana Maria Radulescu
title	Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
title_short	Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
title_full	Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
title_fullStr	Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
title_full_unstemmed	Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
title_sort	randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/6531b4ff04b24080a7d2262f5dfae04b
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Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells

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