A simulation study investigating potential diffusion-based MRI signatures of microstrokes

Abstract Recent studies suggested that cerebrovascular micro-occlusions, i.e. microstokes, could lead to ischemic tissue infarctions and cognitive deficits. Due to their small size, identifying measurable biomarkers of these microvascular lesions remains a major challenge. This work aims to simulate...

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Autores principales:	Rafat Damseh, Yuankang Lu, Xuecong Lu, Cong Zhang, Paul J. Marchand, Denis Corbin, Philippe Pouliot, Farida Cheriet, Frederic Lesage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65332db851814143a37c7f17b0004bb5
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spelling	oai:doaj.org-article:65332db851814143a37c7f17b0004bb52021-12-02T16:14:55ZA simulation study investigating potential diffusion-based MRI signatures of microstrokes10.1038/s41598-021-93503-22045-2322https://doaj.org/article/65332db851814143a37c7f17b0004bb52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93503-2https://doaj.org/toc/2045-2322Abstract Recent studies suggested that cerebrovascular micro-occlusions, i.e. microstokes, could lead to ischemic tissue infarctions and cognitive deficits. Due to their small size, identifying measurable biomarkers of these microvascular lesions remains a major challenge. This work aims to simulate potential MRI signatures combining arterial spin labeling (ASL) and multi-directional diffusion-weighted imaging (DWI). Driving our hypothesis are recent observations demonstrating a radial reorientation of microvasculature around the micro-infarction locus during recovery in mice. Synthetic capillary beds, randomly- and radially-oriented, and optical coherence tomography (OCT) angiograms, acquired in the barrel cortex of mice (n = 5) before and after inducing targeted photothrombosis, were analyzed. Computational vascular graphs combined with a 3D Monte-Carlo simulator were used to characterize the magnetic resonance (MR) response, encompassing the effects of magnetic field perturbations caused by deoxyhemoglobin, and the advection and diffusion of the nuclear spins. We quantified the minimal intravoxel signal loss ratio when applying multiple gradient directions, at varying sequence parameters with and without ASL. With ASL, our results demonstrate a significant difference (p < 0.05) between the signal-ratios computed at baseline and 3 weeks after photothrombosis. The statistical power further increased (p < 0.005) using angiograms measured at week 4. Without ASL, no reliable signal change was found. We found that higher ratios, and accordingly improved significance, were achieved at lower magnetic field strengths (e.g., B0 = 3T) and shorter echo time TE (< 16 ms). Our simulations suggest that microstrokes might be characterized through ASL-DWI sequence, providing necessary insights for posterior experimental validations, and ultimately, future translational trials.Rafat DamsehYuankang LuXuecong LuCong ZhangPaul J. MarchandDenis CorbinPhilippe PouliotFarida CherietFrederic LesageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rafat Damseh Yuankang Lu Xuecong Lu Cong Zhang Paul J. Marchand Denis Corbin Philippe Pouliot Farida Cheriet Frederic Lesage A simulation study investigating potential diffusion-based MRI signatures of microstrokes
description	Abstract Recent studies suggested that cerebrovascular micro-occlusions, i.e. microstokes, could lead to ischemic tissue infarctions and cognitive deficits. Due to their small size, identifying measurable biomarkers of these microvascular lesions remains a major challenge. This work aims to simulate potential MRI signatures combining arterial spin labeling (ASL) and multi-directional diffusion-weighted imaging (DWI). Driving our hypothesis are recent observations demonstrating a radial reorientation of microvasculature around the micro-infarction locus during recovery in mice. Synthetic capillary beds, randomly- and radially-oriented, and optical coherence tomography (OCT) angiograms, acquired in the barrel cortex of mice (n = 5) before and after inducing targeted photothrombosis, were analyzed. Computational vascular graphs combined with a 3D Monte-Carlo simulator were used to characterize the magnetic resonance (MR) response, encompassing the effects of magnetic field perturbations caused by deoxyhemoglobin, and the advection and diffusion of the nuclear spins. We quantified the minimal intravoxel signal loss ratio when applying multiple gradient directions, at varying sequence parameters with and without ASL. With ASL, our results demonstrate a significant difference (p < 0.05) between the signal-ratios computed at baseline and 3 weeks after photothrombosis. The statistical power further increased (p < 0.005) using angiograms measured at week 4. Without ASL, no reliable signal change was found. We found that higher ratios, and accordingly improved significance, were achieved at lower magnetic field strengths (e.g., B0 = 3T) and shorter echo time TE (< 16 ms). Our simulations suggest that microstrokes might be characterized through ASL-DWI sequence, providing necessary insights for posterior experimental validations, and ultimately, future translational trials.
format	article
author	Rafat Damseh Yuankang Lu Xuecong Lu Cong Zhang Paul J. Marchand Denis Corbin Philippe Pouliot Farida Cheriet Frederic Lesage
author_facet	Rafat Damseh Yuankang Lu Xuecong Lu Cong Zhang Paul J. Marchand Denis Corbin Philippe Pouliot Farida Cheriet Frederic Lesage
author_sort	Rafat Damseh
title	A simulation study investigating potential diffusion-based MRI signatures of microstrokes
title_short	A simulation study investigating potential diffusion-based MRI signatures of microstrokes
title_full	A simulation study investigating potential diffusion-based MRI signatures of microstrokes
title_fullStr	A simulation study investigating potential diffusion-based MRI signatures of microstrokes
title_full_unstemmed	A simulation study investigating potential diffusion-based MRI signatures of microstrokes
title_sort	simulation study investigating potential diffusion-based mri signatures of microstrokes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65332db851814143a37c7f17b0004bb5
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A simulation study investigating potential diffusion-based MRI signatures of microstrokes

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