The clinical and cellular basis of contact lens-related corneal infections

Danielle M Robertson, H Dwight CavanaghDepartment of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: Microbial keratitis (MK) is the most visually devastating complication associated with contact lens wear. Pseudomonas aeruginosa (PA) is highly invasive i...

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Autores principales:	Danielle M Robertson, H Dwight Cavanagh
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/653682a513bd49e4a0ed36fbaf67ed7e
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spelling	oai:doaj.org-article:653682a513bd49e4a0ed36fbaf67ed7e2021-12-02T03:09:36ZThe clinical and cellular basis of contact lens-related corneal infections1177-54671177-5483https://doaj.org/article/653682a513bd49e4a0ed36fbaf67ed7e2008-08-01T00:00:00Zhttp://www.dovepress.com/the-clinical-and-cellular-basis-of-contact-lens-related-corneal-infect-a2032https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Danielle M Robertson, H Dwight CavanaghDepartment of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: Microbial keratitis (MK) is the most visually devastating complication associated with contact lens wear. Pseudomonas aeruginosa (PA) is highly invasive in the corneal epithelium and is responsible for more than half of the reported cases of contact lens-related MK. To protect against Pseudomonas-mediated MK, the corneal epithelium has evolved overlapping defense mechanisms that function to protect the ocular surface from microbial invasion. Research has shown that contact lens wear disrupts these protective mechanisms through breakdown of normal homeostatic surface renewal as well as damaging the corneal surface, exposing underlying cell membrane receptors that bind and internalize PA through the formation of lipid rafts. Human clinical trials have shown that initial adherence of PA with resulting increased risk for microbial infection is mediated in part by contact lens oxygen transmissibility. Recently, chemical preserved multipurpose solutions (MPS) have been implicated in increasing PA adherence to corneal epithelial cells, in addition to inducing significant levels of toxic staining when used in conjunction with specific silicone hydrogel lenses. This review summarizes what is currently known about the relationship between contact lenses, the corneal epithelium, MPS, and infection.Keywords: cornea, epithelium, contact lens, microbial keratitis Danielle M RobertsonH Dwight CavanaghDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 907-917 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Danielle M Robertson H Dwight Cavanagh The clinical and cellular basis of contact lens-related corneal infections
description	Danielle M Robertson, H Dwight CavanaghDepartment of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: Microbial keratitis (MK) is the most visually devastating complication associated with contact lens wear. Pseudomonas aeruginosa (PA) is highly invasive in the corneal epithelium and is responsible for more than half of the reported cases of contact lens-related MK. To protect against Pseudomonas-mediated MK, the corneal epithelium has evolved overlapping defense mechanisms that function to protect the ocular surface from microbial invasion. Research has shown that contact lens wear disrupts these protective mechanisms through breakdown of normal homeostatic surface renewal as well as damaging the corneal surface, exposing underlying cell membrane receptors that bind and internalize PA through the formation of lipid rafts. Human clinical trials have shown that initial adherence of PA with resulting increased risk for microbial infection is mediated in part by contact lens oxygen transmissibility. Recently, chemical preserved multipurpose solutions (MPS) have been implicated in increasing PA adherence to corneal epithelial cells, in addition to inducing significant levels of toxic staining when used in conjunction with specific silicone hydrogel lenses. This review summarizes what is currently known about the relationship between contact lenses, the corneal epithelium, MPS, and infection.Keywords: cornea, epithelium, contact lens, microbial keratitis
format	article
author	Danielle M Robertson H Dwight Cavanagh
author_facet	Danielle M Robertson H Dwight Cavanagh
author_sort	Danielle M Robertson
title	The clinical and cellular basis of contact lens-related corneal infections
title_short	The clinical and cellular basis of contact lens-related corneal infections
title_full	The clinical and cellular basis of contact lens-related corneal infections
title_fullStr	The clinical and cellular basis of contact lens-related corneal infections
title_full_unstemmed	The clinical and cellular basis of contact lens-related corneal infections
title_sort	clinical and cellular basis of contact lens-related corneal infections
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/653682a513bd49e4a0ed36fbaf67ed7e
work_keys_str_mv	AT daniellemrobertson theclinicalandcellularbasisofcontactlensrelatedcornealinfections AT hdwightcavanagh theclinicalandcellularbasisofcontactlensrelatedcornealinfections AT daniellemrobertson clinicalandcellularbasisofcontactlensrelatedcornealinfections AT hdwightcavanagh clinicalandcellularbasisofcontactlensrelatedcornealinfections
_version_	1718401921334640640

The clinical and cellular basis of contact lens-related corneal infections

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