Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
ABSTRACT Epigenetic regulation is based on a network of complexes that modulate the chromatin character and structure of the genome to impact gene expression, cell fate, and development. Thus, epigenetic modulators represent novel therapeutic targets used to treat a range of diseases, including mali...
Guardado en:
Autores principales: | Jesse H. Arbuckle, Paul J. Gardina, David N. Gordon, Heather D. Hickman, Jonathan W. Yewdell, Theodore C. Pierson, Timothy G. Myers, Thomas M. Kristie |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6536961d25844f508d6e7f7c04d5f1cf |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA
por: Krystal K. Lum, et al.
Publicado: (2019) -
ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review
por: Mengdi Zhang, et al.
Publicado: (2021) -
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, <named-content content-type="genus-species">Crassostrea gigas</named-content>
por: Maxime Lafont, et al.
Publicado: (2020) -
Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment
por: Glauco Akelinghton Freire Vitiello, et al.
Publicado: (2021) -
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer
por: Lishu He, et al.
Publicado: (2021)