Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.

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Detalles Bibliográficos
Autores principales: Ran Zhang, Guangxue Xu, Lin Cao, Zixian Sun, Yong He, Mengtian Cui, Yuna Sun, Shentao Li, Huapeng Li, Lan Qin, Mingxu Hu, Zhengjia Yuan, Zipei Rao, Wei Ding, Zihe Rao, Zhiyong Lou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/65392197bcba492bad7e082068fe56c1
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Descripción
Sumario:Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.

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