Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.

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Autores principales: Ran Zhang, Guangxue Xu, Lin Cao, Zixian Sun, Yong He, Mengtian Cui, Yuna Sun, Shentao Li, Huapeng Li, Lan Qin, Mingxu Hu, Zhengjia Yuan, Zipei Rao, Wei Ding, Zihe Rao, Zhiyong Lou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/65392197bcba492bad7e082068fe56c1
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spelling oai:doaj.org-article:65392197bcba492bad7e082068fe56c12021-12-02T15:35:39ZDivergent engagements between adeno-associated viruses with their cellular receptor AAVR10.1038/s41467-019-11668-x2041-1723https://doaj.org/article/65392197bcba492bad7e082068fe56c12019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11668-xhttps://doaj.org/toc/2041-1723Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.Ran ZhangGuangxue XuLin CaoZixian SunYong HeMengtian CuiYuna SunShentao LiHuapeng LiLan QinMingxu HuZhengjia YuanZipei RaoWei DingZihe RaoZhiyong LouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ran Zhang
Guangxue Xu
Lin Cao
Zixian Sun
Yong He
Mengtian Cui
Yuna Sun
Shentao Li
Huapeng Li
Lan Qin
Mingxu Hu
Zhengjia Yuan
Zipei Rao
Wei Ding
Zihe Rao
Zhiyong Lou
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
description Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.
format article
author Ran Zhang
Guangxue Xu
Lin Cao
Zixian Sun
Yong He
Mengtian Cui
Yuna Sun
Shentao Li
Huapeng Li
Lan Qin
Mingxu Hu
Zhengjia Yuan
Zipei Rao
Wei Ding
Zihe Rao
Zhiyong Lou
author_facet Ran Zhang
Guangxue Xu
Lin Cao
Zixian Sun
Yong He
Mengtian Cui
Yuna Sun
Shentao Li
Huapeng Li
Lan Qin
Mingxu Hu
Zhengjia Yuan
Zipei Rao
Wei Ding
Zihe Rao
Zhiyong Lou
author_sort Ran Zhang
title Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
title_short Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
title_full Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
title_fullStr Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
title_full_unstemmed Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
title_sort divergent engagements between adeno-associated viruses with their cellular receptor aavr
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/65392197bcba492bad7e082068fe56c1
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