NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

Abstract During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We found that Nos2 −/− mice incapable of...

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Main Authors: Martin Gengenbacher, Maria A. Duque-Correa, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Ulrike Zedler, Stephen T. Reece, Amit Nayyar, Stewart T. Cole, Vadim Makarov, Clifton E. Barry III, Véronique Dartois, Stefan H. E. Kaufmann
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/653956e7764245f0bc27af8e6d730cfa
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https://doaj.org/article/653956e7764245f0bc27af8e6d730cfa

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