Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients

ObjectivesCough impairment may lead to excessive accumulation of pulmonary secretions and increase the risk of postoperative pulmonary complications (PPCs). Peak expiratory flow (PEF) is a sensitive indicator of cough ability. We aimed to investigate the correlation between PEF and PPCs for lung can...

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Autores principales:	Shuai Chang, Kun Zhou, Yan Wang, Yutian Lai, Guowei Che
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	peak expiratory flow (PEF) postoperative pulmonary complications lung neoplasms pulmonary surgical procedures pulmonary rehabilitation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/653db180e1ca4204af36a4d0764f351a
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spelling	oai:doaj.org-article:653db180e1ca4204af36a4d0764f351a2021-11-22T04:49:34ZPrognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients2234-943X10.3389/fonc.2021.782774https://doaj.org/article/653db180e1ca4204af36a4d0764f351a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.782774/fullhttps://doaj.org/toc/2234-943XObjectivesCough impairment may lead to excessive accumulation of pulmonary secretions and increase the risk of postoperative pulmonary complications (PPCs). Peak expiratory flow (PEF) is a sensitive indicator of cough ability. We aimed to investigate the correlation between PEF and PPCs for lung cancer patients undergoing lobectomy or segmental resection for improved risk assessment.MethodsThis retrospective study assessed 560 patients with non-small cell lung cancer admitted for surgery between January 2014 to June 2016. The measurements of PEF were performed before surgery and the clinical outcomes were recorded, including PPCs, postoperative hospital stay, hospitalization costs, and other variables.ResultsPreoperative PEF was significantly lower in PPCs group compared to non-PPCs group (294.2 ± 95.7 vs. 363.0 ± 105.6 L/min, P < 0.001). Multivariable regression analysis showed that high PEF (OR=0.991, 95%CI: 0.988-0.993, P < 0.001) was an independent protective factor for PPCs. According to the receiver operating characteristic (ROC) curve, a PEF value of 250 L/min was selected as the optimal cutoff value in female patients, and 320 L/min in male patients. Patients with PEF under cutoff value of either sex had higher PPCs rate and unfavorable clinical outcomes.ConclusionsPreoperative PEF was found to be a significant predictor of PPCs for surgical lung cancer patients. It may be beneficial to consider the cutoff value of PEF in perioperative risk assessment.Shuai ChangKun ZhouKun ZhouYan WangYutian LaiYutian LaiGuowei CheFrontiers Media S.A.articlepeak expiratory flow (PEF)postoperative pulmonary complicationslung neoplasmspulmonary surgical procedurespulmonary rehabilitationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peak expiratory flow (PEF) postoperative pulmonary complications lung neoplasms pulmonary surgical procedures pulmonary rehabilitation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	peak expiratory flow (PEF) postoperative pulmonary complications lung neoplasms pulmonary surgical procedures pulmonary rehabilitation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shuai Chang Kun Zhou Kun Zhou Yan Wang Yutian Lai Yutian Lai Guowei Che Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
description	ObjectivesCough impairment may lead to excessive accumulation of pulmonary secretions and increase the risk of postoperative pulmonary complications (PPCs). Peak expiratory flow (PEF) is a sensitive indicator of cough ability. We aimed to investigate the correlation between PEF and PPCs for lung cancer patients undergoing lobectomy or segmental resection for improved risk assessment.MethodsThis retrospective study assessed 560 patients with non-small cell lung cancer admitted for surgery between January 2014 to June 2016. The measurements of PEF were performed before surgery and the clinical outcomes were recorded, including PPCs, postoperative hospital stay, hospitalization costs, and other variables.ResultsPreoperative PEF was significantly lower in PPCs group compared to non-PPCs group (294.2 ± 95.7 vs. 363.0 ± 105.6 L/min, P < 0.001). Multivariable regression analysis showed that high PEF (OR=0.991, 95%CI: 0.988-0.993, P < 0.001) was an independent protective factor for PPCs. According to the receiver operating characteristic (ROC) curve, a PEF value of 250 L/min was selected as the optimal cutoff value in female patients, and 320 L/min in male patients. Patients with PEF under cutoff value of either sex had higher PPCs rate and unfavorable clinical outcomes.ConclusionsPreoperative PEF was found to be a significant predictor of PPCs for surgical lung cancer patients. It may be beneficial to consider the cutoff value of PEF in perioperative risk assessment.
format	article
author	Shuai Chang Kun Zhou Kun Zhou Yan Wang Yutian Lai Yutian Lai Guowei Che
author_facet	Shuai Chang Kun Zhou Kun Zhou Yan Wang Yutian Lai Yutian Lai Guowei Che
author_sort	Shuai Chang
title	Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
title_short	Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
title_full	Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
title_fullStr	Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
title_full_unstemmed	Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients
title_sort	prognostic value of preoperative peak expiratory flow to predict postoperative pulmonary complications in surgical lung cancer patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/653db180e1ca4204af36a4d0764f351a
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Prognostic Value of Preoperative Peak Expiratory Flow to Predict Postoperative Pulmonary Complications in Surgical Lung Cancer Patients

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