First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?

Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like react...

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Autores principales:	Jan-Gerd Rademacher, Björn Tampe, Peter Korsten
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sarcoidosis Löfgren’s syndrome vaccination SARS-CoV-2 COVID-19 Medicine R
Acceso en línea:	https://doaj.org/article/6543d1df33dc47f9ace952bdccce71e8
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spelling	oai:doaj.org-article:6543d1df33dc47f9ace952bdccce71e82021-11-25T19:11:14ZFirst Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?10.3390/vaccines91113132076-393Xhttps://doaj.org/article/6543d1df33dc47f9ace952bdccce71e82021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1313https://doaj.org/toc/2076-393XSarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of <i>de novo</i> LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.Jan-Gerd RademacherBjörn TampePeter KorstenMDPI AGarticlesarcoidosisLöfgren’s syndromevaccinationSARS-CoV-2COVID-19MedicineRENVaccines, Vol 9, Iss 1313, p 1313 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcoidosis Löfgren’s syndrome vaccination SARS-CoV-2 COVID-19 Medicine R
spellingShingle	sarcoidosis Löfgren’s syndrome vaccination SARS-CoV-2 COVID-19 Medicine R Jan-Gerd Rademacher Björn Tampe Peter Korsten First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
description	Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of <i>de novo</i> LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.
format	article
author	Jan-Gerd Rademacher Björn Tampe Peter Korsten
author_facet	Jan-Gerd Rademacher Björn Tampe Peter Korsten
author_sort	Jan-Gerd Rademacher
title	First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
title_short	First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
title_full	First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
title_fullStr	First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
title_full_unstemmed	First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
title_sort	first report of two cases of löfgren’s syndrome after sars-cov-2 vaccination-coincidence or causality?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6543d1df33dc47f9ace952bdccce71e8
work_keys_str_mv	AT jangerdrademacher firstreportoftwocasesoflofgrenssyndromeaftersarscov2vaccinationcoincidenceorcausality AT bjorntampe firstreportoftwocasesoflofgrenssyndromeaftersarscov2vaccinationcoincidenceorcausality AT peterkorsten firstreportoftwocasesoflofgrenssyndromeaftersarscov2vaccinationcoincidenceorcausality
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First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?

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