Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic differences between responders and non-responders to...

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Autores principales: Katrin Aslan, Verena Turco, Jens Blobner, Jana K. Sonner, Anna Rita Liuzzi, Nicolás Gonzalo Núñez, Donatella De Feo, Philipp Kickingereder, Manuel Fischer, Ed Green, Ahmed Sadik, Mirco Friedrich, Khwab Sanghvi, Michael Kilian, Frederik Cichon, Lara Wolf, Kristine Jähne, Anna von Landenberg, Lukas Bunse, Felix Sahm, Daniel Schrimpf, Jochen Meyer, Allen Alexander, Gianluca Brugnara, Ralph Röth, Kira Pfleiderer, Beate Niesler, Andreas von Deimling, Christiane Opitz, Michael O. Breckwoldt, Sabine Heiland, Martin Bendszus, Wolfgang Wick, Burkhard Becher, Michael Platten
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/65441a7f16a24904a9e706ac1ace56b2
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spelling oai:doaj.org-article:65441a7f16a24904a9e706ac1ace56b22021-12-02T15:39:17ZHeterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas10.1038/s41467-020-14642-02041-1723https://doaj.org/article/65441a7f16a24904a9e706ac1ace56b22020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14642-0https://doaj.org/toc/2041-1723Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic differences between responders and non-responders to immunotherapy.Katrin AslanVerena TurcoJens BlobnerJana K. SonnerAnna Rita LiuzziNicolás Gonzalo NúñezDonatella De FeoPhilipp KickingerederManuel FischerEd GreenAhmed SadikMirco FriedrichKhwab SanghviMichael KilianFrederik CichonLara WolfKristine JähneAnna von LandenbergLukas BunseFelix SahmDaniel SchrimpfJochen MeyerAllen AlexanderGianluca BrugnaraRalph RöthKira PfleidererBeate NieslerAndreas von DeimlingChristiane OpitzMichael O. BreckwoldtSabine HeilandMartin BendszusWolfgang WickBurkhard BecherMichael PlattenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katrin Aslan
Verena Turco
Jens Blobner
Jana K. Sonner
Anna Rita Liuzzi
Nicolás Gonzalo Núñez
Donatella De Feo
Philipp Kickingereder
Manuel Fischer
Ed Green
Ahmed Sadik
Mirco Friedrich
Khwab Sanghvi
Michael Kilian
Frederik Cichon
Lara Wolf
Kristine Jähne
Anna von Landenberg
Lukas Bunse
Felix Sahm
Daniel Schrimpf
Jochen Meyer
Allen Alexander
Gianluca Brugnara
Ralph Röth
Kira Pfleiderer
Beate Niesler
Andreas von Deimling
Christiane Opitz
Michael O. Breckwoldt
Sabine Heiland
Martin Bendszus
Wolfgang Wick
Burkhard Becher
Michael Platten
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
description Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic differences between responders and non-responders to immunotherapy.
format article
author Katrin Aslan
Verena Turco
Jens Blobner
Jana K. Sonner
Anna Rita Liuzzi
Nicolás Gonzalo Núñez
Donatella De Feo
Philipp Kickingereder
Manuel Fischer
Ed Green
Ahmed Sadik
Mirco Friedrich
Khwab Sanghvi
Michael Kilian
Frederik Cichon
Lara Wolf
Kristine Jähne
Anna von Landenberg
Lukas Bunse
Felix Sahm
Daniel Schrimpf
Jochen Meyer
Allen Alexander
Gianluca Brugnara
Ralph Röth
Kira Pfleiderer
Beate Niesler
Andreas von Deimling
Christiane Opitz
Michael O. Breckwoldt
Sabine Heiland
Martin Bendszus
Wolfgang Wick
Burkhard Becher
Michael Platten
author_facet Katrin Aslan
Verena Turco
Jens Blobner
Jana K. Sonner
Anna Rita Liuzzi
Nicolás Gonzalo Núñez
Donatella De Feo
Philipp Kickingereder
Manuel Fischer
Ed Green
Ahmed Sadik
Mirco Friedrich
Khwab Sanghvi
Michael Kilian
Frederik Cichon
Lara Wolf
Kristine Jähne
Anna von Landenberg
Lukas Bunse
Felix Sahm
Daniel Schrimpf
Jochen Meyer
Allen Alexander
Gianluca Brugnara
Ralph Röth
Kira Pfleiderer
Beate Niesler
Andreas von Deimling
Christiane Opitz
Michael O. Breckwoldt
Sabine Heiland
Martin Bendszus
Wolfgang Wick
Burkhard Becher
Michael Platten
author_sort Katrin Aslan
title Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
title_short Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
title_full Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
title_fullStr Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
title_full_unstemmed Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
title_sort heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/65441a7f16a24904a9e706ac1ace56b2
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