HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be critical for controlling HIV infection. In the current...

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Autores principales: Tomer Hertz, Hasan Ahmed, David P Friedrich, Danilo R Casimiro, Steven G Self, Lawrence Corey, M Juliana McElrath, Susan Buchbinder, Helen Horton, Nicole Frahm, Michael N Robertson, Barney S Graham, Peter Gilbert
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/65453933a1c548b5b4a92a58148c1113
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