DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Transcriptional changes occur in the dorsal root ganglion in response to nerve injury and may contribute to neuropathic pain. Here the authors show that the DNA methyltransferase DNMT3a is upregulated in rodents following nerve injury, and may contribute to pain-like behaviour by decreasing expressi...

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Autores principales:	Jian-Yuan Zhao, Lingli Liang, Xiyao Gu, Zhisong Li, Shaogen Wu, Linlin Sun, Fidelis E. Atianjoh, Jian Feng, Kai Mo, Shushan Jia, Brianna Marie Lutz, Alex Bekker, Eric J. Nestler, Yuan-Xiang Tao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6546e90f8d0a479b8916bd70184ce7f5
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spelling	oai:doaj.org-article:6546e90f8d0a479b8916bd70184ce7f52021-12-02T17:06:12ZDNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons10.1038/ncomms147122041-1723https://doaj.org/article/6546e90f8d0a479b8916bd70184ce7f52017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14712https://doaj.org/toc/2041-1723Transcriptional changes occur in the dorsal root ganglion in response to nerve injury and may contribute to neuropathic pain. Here the authors show that the DNA methyltransferase DNMT3a is upregulated in rodents following nerve injury, and may contribute to pain-like behaviour by decreasing expression of the voltage-gated potassium channel Kv1.2.Jian-Yuan ZhaoLingli LiangXiyao GuZhisong LiShaogen WuLinlin SunFidelis E. AtianjohJian FengKai MoShushan JiaBrianna Marie LutzAlex BekkerEric J. NestlerYuan-Xiang TaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian-Yuan Zhao Lingli Liang Xiyao Gu Zhisong Li Shaogen Wu Linlin Sun Fidelis E. Atianjoh Jian Feng Kai Mo Shushan Jia Brianna Marie Lutz Alex Bekker Eric J. Nestler Yuan-Xiang Tao DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
description	Transcriptional changes occur in the dorsal root ganglion in response to nerve injury and may contribute to neuropathic pain. Here the authors show that the DNA methyltransferase DNMT3a is upregulated in rodents following nerve injury, and may contribute to pain-like behaviour by decreasing expression of the voltage-gated potassium channel Kv1.2.
format	article
author	Jian-Yuan Zhao Lingli Liang Xiyao Gu Zhisong Li Shaogen Wu Linlin Sun Fidelis E. Atianjoh Jian Feng Kai Mo Shushan Jia Brianna Marie Lutz Alex Bekker Eric J. Nestler Yuan-Xiang Tao
author_facet	Jian-Yuan Zhao Lingli Liang Xiyao Gu Zhisong Li Shaogen Wu Linlin Sun Fidelis E. Atianjoh Jian Feng Kai Mo Shushan Jia Brianna Marie Lutz Alex Bekker Eric J. Nestler Yuan-Xiang Tao
author_sort	Jian-Yuan Zhao
title	DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
title_short	DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
title_full	DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
title_fullStr	DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
title_full_unstemmed	DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
title_sort	dna methyltransferase dnmt3a contributes to neuropathic pain by repressing kcna2 in primary afferent neurons
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6546e90f8d0a479b8916bd70184ce7f5
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DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

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