Cisplatin is retained in the cochlea indefinitely following chemotherapy

Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.

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Autores principales:	Andrew M. Breglio, Aaron E. Rusheen, Eric D. Shide, Katharine A. Fernandez, Katie K. Spielbauer, Katherine M. McLachlin, Matthew D. Hall, Lauren Amable, Lisa L. Cunningham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/654bf441556b449db69facaa3c80c8f7
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spelling	oai:doaj.org-article:654bf441556b449db69facaa3c80c8f72021-12-02T15:37:03ZCisplatin is retained in the cochlea indefinitely following chemotherapy10.1038/s41467-017-01837-12041-1723https://doaj.org/article/654bf441556b449db69facaa3c80c8f72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01837-1https://doaj.org/toc/2041-1723Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.Andrew M. BreglioAaron E. RusheenEric D. ShideKatharine A. FernandezKatie K. SpielbauerKatherine M. McLachlinMatthew D. HallLauren AmableLisa L. CunninghamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew M. Breglio Aaron E. Rusheen Eric D. Shide Katharine A. Fernandez Katie K. Spielbauer Katherine M. McLachlin Matthew D. Hall Lauren Amable Lisa L. Cunningham Cisplatin is retained in the cochlea indefinitely following chemotherapy
description	Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.
format	article
author	Andrew M. Breglio Aaron E. Rusheen Eric D. Shide Katharine A. Fernandez Katie K. Spielbauer Katherine M. McLachlin Matthew D. Hall Lauren Amable Lisa L. Cunningham
author_facet	Andrew M. Breglio Aaron E. Rusheen Eric D. Shide Katharine A. Fernandez Katie K. Spielbauer Katherine M. McLachlin Matthew D. Hall Lauren Amable Lisa L. Cunningham
author_sort	Andrew M. Breglio
title	Cisplatin is retained in the cochlea indefinitely following chemotherapy
title_short	Cisplatin is retained in the cochlea indefinitely following chemotherapy
title_full	Cisplatin is retained in the cochlea indefinitely following chemotherapy
title_fullStr	Cisplatin is retained in the cochlea indefinitely following chemotherapy
title_full_unstemmed	Cisplatin is retained in the cochlea indefinitely following chemotherapy
title_sort	cisplatin is retained in the cochlea indefinitely following chemotherapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/654bf441556b449db69facaa3c80c8f7
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Cisplatin is retained in the cochlea indefinitely following chemotherapy

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