How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and charac...

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Autores principales:	Dorien Clarisse, Karolien De Bosscher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/654e0ecf4dbe442bb12413eb1bce88ce
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spelling	oai:doaj.org-article:654e0ecf4dbe442bb12413eb1bce88ce2021-12-02T18:01:12ZHow the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer10.1038/s41467-021-24847-62041-1723https://doaj.org/article/654e0ecf4dbe442bb12413eb1bce88ce2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24847-6https://doaj.org/toc/2041-1723Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and characterized avenues towards a viable escape strategy.Dorien ClarisseKarolien De BosscherNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dorien Clarisse Karolien De Bosscher How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
description	Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and characterized avenues towards a viable escape strategy.
format	article
author	Dorien Clarisse Karolien De Bosscher
author_facet	Dorien Clarisse Karolien De Bosscher
author_sort	Dorien Clarisse
title	How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_short	How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_full	How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_fullStr	How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_full_unstemmed	How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_sort	how the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/654e0ecf4dbe442bb12413eb1bce88ce
work_keys_str_mv	AT dorienclarisse howtheglucocorticoidreceptorcontributestoplatinumbasedtherapyresistanceinsolidcancer AT karoliendebosscher howtheglucocorticoidreceptorcontributestoplatinumbasedtherapyresistanceinsolidcancer
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How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

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