Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

Our current understanding of exosome signaling among CNS cells is mostly limited to culture models. In this study, authors generated a new cell-type specific exosome reporter mouse line which allows the first in vivo investigation of the localization of neuronal exosomes in the CNS, and also potenti...

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Autores principales:	Yuqin Men, Julia Yelick, Shijie Jin, Yang Tian, Ming Sum R. Chiang, Haruki Higashimori, Eoin Brown, Rachel Jarvis, Yongjie Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/655139c6afd141fbba643ad0ce0b3b1b
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spelling	oai:doaj.org-article:655139c6afd141fbba643ad0ce0b3b1b2021-12-02T17:02:02ZExosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS10.1038/s41467-019-11534-w2041-1723https://doaj.org/article/655139c6afd141fbba643ad0ce0b3b1b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11534-whttps://doaj.org/toc/2041-1723Our current understanding of exosome signaling among CNS cells is mostly limited to culture models. In this study, authors generated a new cell-type specific exosome reporter mouse line which allows the first in vivo investigation of the localization of neuronal exosomes in the CNS, and also potentially highlights the role of exosomally transferred miR-124-3p in mediating astroglial glutamate uptake functionYuqin MenJulia YelickShijie JinYang TianMing Sum R. ChiangHaruki HigashimoriEoin BrownRachel JarvisYongjie YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuqin Men Julia Yelick Shijie Jin Yang Tian Ming Sum R. Chiang Haruki Higashimori Eoin Brown Rachel Jarvis Yongjie Yang Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
description	Our current understanding of exosome signaling among CNS cells is mostly limited to culture models. In this study, authors generated a new cell-type specific exosome reporter mouse line which allows the first in vivo investigation of the localization of neuronal exosomes in the CNS, and also potentially highlights the role of exosomally transferred miR-124-3p in mediating astroglial glutamate uptake function
format	article
author	Yuqin Men Julia Yelick Shijie Jin Yang Tian Ming Sum R. Chiang Haruki Higashimori Eoin Brown Rachel Jarvis Yongjie Yang
author_facet	Yuqin Men Julia Yelick Shijie Jin Yang Tian Ming Sum R. Chiang Haruki Higashimori Eoin Brown Rachel Jarvis Yongjie Yang
author_sort	Yuqin Men
title	Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
title_short	Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
title_full	Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
title_fullStr	Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
title_full_unstemmed	Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS
title_sort	exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the cns
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/655139c6afd141fbba643ad0ce0b3b1b
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Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

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