Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California

Abstract Clinic-based estimates of SARS-CoV-2 may considerably underestimate the total number of infections. Access to testing in the US has been heterogeneous and symptoms vary widely in infected persons. Public health surveillance efforts and metrics are therefore hampered by underreporting. We se...

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Autores principales:	Tim A. Bruckner, Daniel M. Parker, Scott M. Bartell, Veronica M. Vieira, Saahir Khan, Andrew Noymer, Emily Drum, Bruce Albala, Matthew Zahn, Bernadette Boden-Albala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6551a2749e4d481891519cd376f5f206
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spelling	oai:doaj.org-article:6551a2749e4d481891519cd376f5f2062021-12-02T14:06:18ZEstimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California10.1038/s41598-021-82662-x2045-2322https://doaj.org/article/6551a2749e4d481891519cd376f5f2062021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82662-xhttps://doaj.org/toc/2045-2322Abstract Clinic-based estimates of SARS-CoV-2 may considerably underestimate the total number of infections. Access to testing in the US has been heterogeneous and symptoms vary widely in infected persons. Public health surveillance efforts and metrics are therefore hampered by underreporting. We set out to provide a minimally biased estimate of SARS-CoV-2 seroprevalence among adults for a large and diverse county (Orange County, CA, population 3.2 million). We implemented a surveillance study that minimizes response bias by recruiting adults to answer a survey without knowledge of later being offered SARS-CoV-2 test. Several methodologies were used to retrieve a population-representative sample. Participants (n = 2979) visited one of 11 drive-thru test sites from July 10th to August 16th, 2020 (or received an in-home visit) to provide a finger pin-prick sample. We applied a robust SARS-CoV-2 Antigen Microarray technology, which has superior measurement validity relative to FDA-approved tests. Participants include a broad age, gender, racial/ethnic, and income representation. Adjusted seroprevalence of SARS-CoV-2 infection was 11.5% (95% CI: 10.5–12.4%). Formal bias analyses produced similar results. Prevalence was elevated among Hispanics (vs. other non-Hispanic: prevalence ratio [PR] = 1.47, 95% CI 1.22–1.78) and household income < $50,000 (vs. > $100,000: PR = 1.42, 95% CI: 1.14 to 1.79). Results from a diverse population using a highly specific and sensitive microarray indicate a SARS-CoV-2 seroprevalence of ~ 12 percent. This population-based seroprevalence is seven-fold greater than that using official County statistics. In this region, SARS-CoV-2 also disproportionately affects Hispanic and low-income adults.Tim A. BrucknerDaniel M. ParkerScott M. BartellVeronica M. VieiraSaahir KhanAndrew NoymerEmily DrumBruce AlbalaMatthew ZahnBernadette Boden-AlbalaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tim A. Bruckner Daniel M. Parker Scott M. Bartell Veronica M. Vieira Saahir Khan Andrew Noymer Emily Drum Bruce Albala Matthew Zahn Bernadette Boden-Albala Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
description	Abstract Clinic-based estimates of SARS-CoV-2 may considerably underestimate the total number of infections. Access to testing in the US has been heterogeneous and symptoms vary widely in infected persons. Public health surveillance efforts and metrics are therefore hampered by underreporting. We set out to provide a minimally biased estimate of SARS-CoV-2 seroprevalence among adults for a large and diverse county (Orange County, CA, population 3.2 million). We implemented a surveillance study that minimizes response bias by recruiting adults to answer a survey without knowledge of later being offered SARS-CoV-2 test. Several methodologies were used to retrieve a population-representative sample. Participants (n = 2979) visited one of 11 drive-thru test sites from July 10th to August 16th, 2020 (or received an in-home visit) to provide a finger pin-prick sample. We applied a robust SARS-CoV-2 Antigen Microarray technology, which has superior measurement validity relative to FDA-approved tests. Participants include a broad age, gender, racial/ethnic, and income representation. Adjusted seroprevalence of SARS-CoV-2 infection was 11.5% (95% CI: 10.5–12.4%). Formal bias analyses produced similar results. Prevalence was elevated among Hispanics (vs. other non-Hispanic: prevalence ratio [PR] = 1.47, 95% CI 1.22–1.78) and household income < $50,000 (vs. > $100,000: PR = 1.42, 95% CI: 1.14 to 1.79). Results from a diverse population using a highly specific and sensitive microarray indicate a SARS-CoV-2 seroprevalence of ~ 12 percent. This population-based seroprevalence is seven-fold greater than that using official County statistics. In this region, SARS-CoV-2 also disproportionately affects Hispanic and low-income adults.
format	article
author	Tim A. Bruckner Daniel M. Parker Scott M. Bartell Veronica M. Vieira Saahir Khan Andrew Noymer Emily Drum Bruce Albala Matthew Zahn Bernadette Boden-Albala
author_facet	Tim A. Bruckner Daniel M. Parker Scott M. Bartell Veronica M. Vieira Saahir Khan Andrew Noymer Emily Drum Bruce Albala Matthew Zahn Bernadette Boden-Albala
author_sort	Tim A. Bruckner
title	Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
title_short	Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
title_full	Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
title_fullStr	Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
title_full_unstemmed	Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California
title_sort	estimated seroprevalence of sars-cov-2 antibodies among adults in orange county, california
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6551a2749e4d481891519cd376f5f206
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Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California

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