Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context

Theory predicts that pathogens will evolve towards intermediate virulence, yet the necessary trade-offs invoked by this theory have rarely been demonstrated empirically. Here, the authors show that dengue virus dynamics exhibit a trade-off between transmission and clearance rates.

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Detalles Bibliográficos
Autores principales:	Rotem Ben-Shachar, Katia Koelle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65534d1c53ab449390d58f6025fa28d3
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spelling	oai:doaj.org-article:65534d1c53ab449390d58f6025fa28d32021-12-02T16:56:52ZTransmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context10.1038/s41467-018-04595-w2041-1723https://doaj.org/article/65534d1c53ab449390d58f6025fa28d32018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04595-whttps://doaj.org/toc/2041-1723Theory predicts that pathogens will evolve towards intermediate virulence, yet the necessary trade-offs invoked by this theory have rarely been demonstrated empirically. Here, the authors show that dengue virus dynamics exhibit a trade-off between transmission and clearance rates.Rotem Ben-ShacharKatia KoelleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rotem Ben-Shachar Katia Koelle Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
description	Theory predicts that pathogens will evolve towards intermediate virulence, yet the necessary trade-offs invoked by this theory have rarely been demonstrated empirically. Here, the authors show that dengue virus dynamics exhibit a trade-off between transmission and clearance rates.
format	article
author	Rotem Ben-Shachar Katia Koelle
author_facet	Rotem Ben-Shachar Katia Koelle
author_sort	Rotem Ben-Shachar
title	Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
title_short	Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
title_full	Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
title_fullStr	Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
title_full_unstemmed	Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
title_sort	transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/65534d1c53ab449390d58f6025fa28d3
work_keys_str_mv	AT rotembenshachar transmissionclearancetradeoffsindicatethatdenguevirulenceevolutiondependsonepidemiologicalcontext AT katiakoelle transmissionclearancetradeoffsindicatethatdenguevirulenceevolutiondependsonepidemiologicalcontext
_version_	1718382684952068096

Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context

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