Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality

Yoshitaka Oka,1 Noriyuki Sasaki,2 Valentine P Injev3 1Senshinkai Eye Institute, Iizuka-shi, Japan; 2Alcon Japan Ltd., Tokyo, Japan; 3Alcon Vision LLC, Lake Forest, CA, USACorrespondence: Yoshitaka OkaSenshinkai Eye Institute, 371-1 Kawazu, Iizuka-shi, Fukuoka-ken, 820-0067, JapanTel +81-948-22-5155E...

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Autores principales:	Oka Y, Sasaki N, Injev VP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cumulative dissipated energy endothelial cell loss lensx torsional phaco. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6554c903d061430c9ef5cc2b68a4ff25
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spelling	oai:doaj.org-article:6554c903d061430c9ef5cc2b68a4ff252021-12-02T16:52:25ZComparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality1177-5483https://doaj.org/article/6554c903d061430c9ef5cc2b68a4ff252021-10-01T00:00:00Zhttps://www.dovepress.com/comparison-of-femtosecond-laser-assisted-cataract-surgery-and-conventi-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Yoshitaka Oka,1 Noriyuki Sasaki,2 Valentine P Injev3 1Senshinkai Eye Institute, Iizuka-shi, Japan; 2Alcon Japan Ltd., Tokyo, Japan; 3Alcon Vision LLC, Lake Forest, CA, USACorrespondence: Yoshitaka OkaSenshinkai Eye Institute, 371-1 Kawazu, Iizuka-shi, Fukuoka-ken, 820-0067, JapanTel +81-948-22-5155Email oka@okaganka.comPurpose: To compare the effects of femtosecond laser assisted cataract surgery (FLACS) and manual phacoemulsification on cumulative dissipated energy (CDE), torsional amplitude, and endothelial cell density (ECD).Patients and Methods: This prospective, randomized study was conducted at Oka Eye Clinic (Fukuoka, Japan). Surgeries were performed using FLACS (with LenSx) or conventional technique in adults ≥ 20 years with grade 2– 4 cataracts. Visits included preoperative, surgery day, and 5 postoperative visits (days 1, 4– 10, 20– 40, 60– 120, and 150– 210). Primary endpoint was CDE. Secondary endpoints included ECD percent change at day 150– 210 versus preoperative visit and average torsional amplitude on surgery day. Exploratory endpoints included central corneal thickness and corrected distance visual acuity (CDVA). Superiority of FLACS to conventional technique was evaluated using t-tests based on a mixed model for repeated measures.Results: Full analysis set included 53 eyes per group. Mean cataract grade was 2.92± 0.58 in FLACS and 2.94± 0.57 in conventional group. FLACS versus conventional method had significantly lower mean CDE (0.213± 0.334 versus 1.718± 0.898%-seconds, respectively; P< 0.0001), demonstrating superiority of FLACS. Low endothelial cell loss (ECL) was achieved with both FLACS and conventional methods (1.5± 5.6% and 2.7± 5.2%; P=0.260). Torsional amplitude was significantly lower for FLACS versus conventional method (19.6± 16.0% versus 31.1± 6.6%; P< 0.0001). Central corneal thickness was comparable for both methods at all visits except day 1; CDVA was comparable for both methods at all postoperative visits.Conclusion: FLACS achieved significantly lower CDE compared with the conventional surgical method (P< 0.0001). Low ECL was achieved with both FLACS (1.5%) and conventional (2.7%) methods.Keywords: cumulative dissipated energy, endothelial cell loss, LenSx, torsional phacoOka YSasaki NInjev VPDove Medical Pressarticlecumulative dissipated energyendothelial cell losslensxtorsional phaco.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4227-4237 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cumulative dissipated energy endothelial cell loss lensx torsional phaco. Ophthalmology RE1-994
spellingShingle	cumulative dissipated energy endothelial cell loss lensx torsional phaco. Ophthalmology RE1-994 Oka Y Sasaki N Injev VP Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
description	Yoshitaka Oka,1 Noriyuki Sasaki,2 Valentine P Injev3 1Senshinkai Eye Institute, Iizuka-shi, Japan; 2Alcon Japan Ltd., Tokyo, Japan; 3Alcon Vision LLC, Lake Forest, CA, USACorrespondence: Yoshitaka OkaSenshinkai Eye Institute, 371-1 Kawazu, Iizuka-shi, Fukuoka-ken, 820-0067, JapanTel +81-948-22-5155Email oka@okaganka.comPurpose: To compare the effects of femtosecond laser assisted cataract surgery (FLACS) and manual phacoemulsification on cumulative dissipated energy (CDE), torsional amplitude, and endothelial cell density (ECD).Patients and Methods: This prospective, randomized study was conducted at Oka Eye Clinic (Fukuoka, Japan). Surgeries were performed using FLACS (with LenSx) or conventional technique in adults ≥ 20 years with grade 2– 4 cataracts. Visits included preoperative, surgery day, and 5 postoperative visits (days 1, 4– 10, 20– 40, 60– 120, and 150– 210). Primary endpoint was CDE. Secondary endpoints included ECD percent change at day 150– 210 versus preoperative visit and average torsional amplitude on surgery day. Exploratory endpoints included central corneal thickness and corrected distance visual acuity (CDVA). Superiority of FLACS to conventional technique was evaluated using t-tests based on a mixed model for repeated measures.Results: Full analysis set included 53 eyes per group. Mean cataract grade was 2.92± 0.58 in FLACS and 2.94± 0.57 in conventional group. FLACS versus conventional method had significantly lower mean CDE (0.213± 0.334 versus 1.718± 0.898%-seconds, respectively; P< 0.0001), demonstrating superiority of FLACS. Low endothelial cell loss (ECL) was achieved with both FLACS and conventional methods (1.5± 5.6% and 2.7± 5.2%; P=0.260). Torsional amplitude was significantly lower for FLACS versus conventional method (19.6± 16.0% versus 31.1± 6.6%; P< 0.0001). Central corneal thickness was comparable for both methods at all visits except day 1; CDVA was comparable for both methods at all postoperative visits.Conclusion: FLACS achieved significantly lower CDE compared with the conventional surgical method (P< 0.0001). Low ECL was achieved with both FLACS (1.5%) and conventional (2.7%) methods.Keywords: cumulative dissipated energy, endothelial cell loss, LenSx, torsional phaco
format	article
author	Oka Y Sasaki N Injev VP
author_facet	Oka Y Sasaki N Injev VP
author_sort	Oka Y
title	Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
title_short	Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
title_full	Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
title_fullStr	Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
title_full_unstemmed	Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality
title_sort	comparison of femtosecond laser-assisted cataract surgery and conventional phacoemulsification on endothelial cell density when using torsional modality
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6554c903d061430c9ef5cc2b68a4ff25
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_version_	1718382921345138688

Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification on Endothelial Cell Density When Using Torsional Modality

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