Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors

The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors. Nevertheless, only a fraction of solid tumors responds to this immunotherapy modality. Another modality of immuno...

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Autores principales:	Mirella Nardo, Tatiane C. Motta, Leandro M. Colli, Mauro P. Avanzi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Immunotherapy CAR-T cells Cell therapy Adoptive cell therapy Checkpoint inhibitors Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/6556afb3af274f31b4fc07c156686c8b
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id	oai:doaj.org-article:6556afb3af274f31b4fc07c156686c8b
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spelling	oai:doaj.org-article:6556afb3af274f31b4fc07c156686c8b2021-11-18T04:51:07ZAssociação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors2531-137910.1016/j.htct.2021.09.011https://doaj.org/article/6556afb3af274f31b4fc07c156686c8b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921001474https://doaj.org/toc/2531-1379The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors. Nevertheless, only a fraction of solid tumors responds to this immunotherapy modality. Another modality of immunotherapy consists of employing cell-based therapy as an adoptive therapeutic modality. That involves distinct modalities of cellular therapies such as CAR T cells (chimeric antigen receptor T cell), TILs (tumor-infiltrating lymphocytes), and TCR T cells. Those treatments have proven effective in hematologic tumors and could have an impact in tumors that do not respond to checkpoint inhibitors. This review aims to outline the rationale, operation, clinical applicability, and results of adoptive cell therapy for patients with solid tumors.Mirella NardoTatiane C. MottaLeandro M. ColliMauro P. AvanziElsevierarticleImmunotherapyCAR-T cellsCell therapyAdoptive cell therapyCheckpoint inhibitorsDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S78-S83 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunotherapy CAR-T cells Cell therapy Adoptive cell therapy Checkpoint inhibitors Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Immunotherapy CAR-T cells Cell therapy Adoptive cell therapy Checkpoint inhibitors Diseases of the blood and blood-forming organs RC633-647.5 Mirella Nardo Tatiane C. Motta Leandro M. Colli Mauro P. Avanzi Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
description	The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors. Nevertheless, only a fraction of solid tumors responds to this immunotherapy modality. Another modality of immunotherapy consists of employing cell-based therapy as an adoptive therapeutic modality. That involves distinct modalities of cellular therapies such as CAR T cells (chimeric antigen receptor T cell), TILs (tumor-infiltrating lymphocytes), and TCR T cells. Those treatments have proven effective in hematologic tumors and could have an impact in tumors that do not respond to checkpoint inhibitors. This review aims to outline the rationale, operation, clinical applicability, and results of adoptive cell therapy for patients with solid tumors.
format	article
author	Mirella Nardo Tatiane C. Motta Leandro M. Colli Mauro P. Avanzi
author_facet	Mirella Nardo Tatiane C. Motta Leandro M. Colli Mauro P. Avanzi
author_sort	Mirella Nardo
title	Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
title_short	Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
title_full	Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
title_fullStr	Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
title_full_unstemmed	Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors
title_sort	associação brasileira de hematologia, hematologia, hemoterapia e terapia celular consensus on genetically modified cells. review article: cell therapy in solid tumors
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6556afb3af274f31b4fc07c156686c8b
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Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors

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