2D Nanosheets—A New Class of Therapeutic Formulations against Cancer

Researchers in cancer nanomedicine are exploring a revolutionary multifaceted carrier for treatment and diagnosis, resulting in the proposal of various drug cargos or “magic bullets” in this past decade. Even though different nano-based complexes are registered for clinical trials, very few products...

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Autores principales:	Ravichandran Manisekaran, René García-Contreras, Aruna-Devi Rasu Chettiar, Paloma Serrano-Díaz, Christian Andrea Lopez-Ayuso, Ma Concepción Arenas-Arrocena, Genoveva Hernández-Padrón, Luz M. López-Marín, Laura Susana Acosta-Torres
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	2D material nanosheets MXene black phosphorus transition metal dichalcogenides LDHs Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/655789198d074e6e918659fdda79ffa1
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spelling	oai:doaj.org-article:655789198d074e6e918659fdda79ffa12021-11-25T18:40:48Z2D Nanosheets—A New Class of Therapeutic Formulations against Cancer10.3390/pharmaceutics131118031999-4923https://doaj.org/article/655789198d074e6e918659fdda79ffa12021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1803https://doaj.org/toc/1999-4923Researchers in cancer nanomedicine are exploring a revolutionary multifaceted carrier for treatment and diagnosis, resulting in the proposal of various drug cargos or “magic bullets” in this past decade. Even though different nano-based complexes are registered for clinical trials, very few products enter the final stages each year because of various issues. This prevents the formulations from entering the market and being accessible to patients. In the search for novel materials, the exploitation of 2D nanosheets, including but not limited to the highly acclaimed graphene, has created extensive interest for biomedical applications. A unique set of properties often characterize 2D materials, including semiconductivity, high surface area, and their chemical nature, which allow simple decoration and functionalization procedures, structures with high stability and targeting properties, vectors for controlled and sustained release of drugs, and materials for thermal-based therapies. This review discusses the challenges and opportunities of recently discovered 2D nanosheets for cancer therapeutics, with special attention paid to the most promising design technologies and their potential for clinical translation in the future.Ravichandran ManisekaranRené García-ContrerasAruna-Devi Rasu ChettiarPaloma Serrano-DíazChristian Andrea Lopez-AyusoMa Concepción Arenas-ArrocenaGenoveva Hernández-PadrónLuz M. López-MarínLaura Susana Acosta-TorresMDPI AGarticle2D materialnanosheetsMXeneblack phosphorustransition metal dichalcogenidesLDHsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1803, p 1803 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	2D material nanosheets MXene black phosphorus transition metal dichalcogenides LDHs Pharmacy and materia medica RS1-441
spellingShingle	2D material nanosheets MXene black phosphorus transition metal dichalcogenides LDHs Pharmacy and materia medica RS1-441 Ravichandran Manisekaran René García-Contreras Aruna-Devi Rasu Chettiar Paloma Serrano-Díaz Christian Andrea Lopez-Ayuso Ma Concepción Arenas-Arrocena Genoveva Hernández-Padrón Luz M. López-Marín Laura Susana Acosta-Torres 2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
description	Researchers in cancer nanomedicine are exploring a revolutionary multifaceted carrier for treatment and diagnosis, resulting in the proposal of various drug cargos or “magic bullets” in this past decade. Even though different nano-based complexes are registered for clinical trials, very few products enter the final stages each year because of various issues. This prevents the formulations from entering the market and being accessible to patients. In the search for novel materials, the exploitation of 2D nanosheets, including but not limited to the highly acclaimed graphene, has created extensive interest for biomedical applications. A unique set of properties often characterize 2D materials, including semiconductivity, high surface area, and their chemical nature, which allow simple decoration and functionalization procedures, structures with high stability and targeting properties, vectors for controlled and sustained release of drugs, and materials for thermal-based therapies. This review discusses the challenges and opportunities of recently discovered 2D nanosheets for cancer therapeutics, with special attention paid to the most promising design technologies and their potential for clinical translation in the future.
format	article
author	Ravichandran Manisekaran René García-Contreras Aruna-Devi Rasu Chettiar Paloma Serrano-Díaz Christian Andrea Lopez-Ayuso Ma Concepción Arenas-Arrocena Genoveva Hernández-Padrón Luz M. López-Marín Laura Susana Acosta-Torres
author_facet	Ravichandran Manisekaran René García-Contreras Aruna-Devi Rasu Chettiar Paloma Serrano-Díaz Christian Andrea Lopez-Ayuso Ma Concepción Arenas-Arrocena Genoveva Hernández-Padrón Luz M. López-Marín Laura Susana Acosta-Torres
author_sort	Ravichandran Manisekaran
title	2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
title_short	2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
title_full	2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
title_fullStr	2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
title_full_unstemmed	2D Nanosheets—A New Class of Therapeutic Formulations against Cancer
title_sort	2d nanosheets—a new class of therapeutic formulations against cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/655789198d074e6e918659fdda79ffa1
work_keys_str_mv	AT ravichandranmanisekaran 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT renegarciacontreras 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT arunadevirasuchettiar 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT palomaserranodiaz 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT christianandrealopezayuso 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT maconcepcionarenasarrocena 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT genovevahernandezpadron 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT luzmlopezmarin 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer AT laurasusanaacostatorres 2dnanosheetsanewclassoftherapeuticformulationsagainstcancer
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2D Nanosheets—A New Class of Therapeutic Formulations against Cancer

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