Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens

Abstract Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it is intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that bone is a highly vascularized tissue dependent on t...

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Autores principales:	Shu-cheng Huang, Li-hong Zhang, Jia-lu Zhang, Mujeeb Ur Rehman, Xiao-le Tong, Gang Qiu, Xiong Jiang, Mujahid Iqbal, Muhammad Shahzad, Yao-qin Shen, Jia-kui Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65590ae0fbd74f21a8a34fe416468cc9
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spelling	oai:doaj.org-article:65590ae0fbd74f21a8a34fe416468cc92021-12-02T15:08:05ZRole and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens10.1038/s41598-018-22109-y2045-2322https://doaj.org/article/65590ae0fbd74f21a8a34fe416468cc92018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22109-yhttps://doaj.org/toc/2045-2322Abstract Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it is intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that bone is a highly vascularized tissue dependent on the coordinated coupling between angiogenesis and osteogenesis, but the underlying mechanisms of bone formation and bone remodeling are poorly defined in TD chickens. Here, we observed that inhibition of vasculogenesis and angiogenesis remarkably impaired vascular invasion in the hypertrophic chondrocyte zone of the TGPs, resulting in the massive death of chondrocytes due to a shortage of blood vessels and nutrients. Moreover, the balance of the OPG (osteoprotegerin)/RANKL (receptor activator of nuclear factor-kB ligand) system is also severely disrupted during the osteogenesis process while coupling with angiogenesis, both of which eventually lead to abnormal endochondral bone formation in TD chickens. Thus, the process of vascular formation in endochondral bone appears to initiate the pathological changes in TD, and improvement of this process during coupling with osteogenesis may be a potential therapeutic approach to treat this intractable disease.Shu-cheng HuangLi-hong ZhangJia-lu ZhangMujeeb Ur RehmanXiao-le TongGang QiuXiong JiangMujahid IqbalMuhammad ShahzadYao-qin ShenJia-kui LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shu-cheng Huang Li-hong Zhang Jia-lu Zhang Mujeeb Ur Rehman Xiao-le Tong Gang Qiu Xiong Jiang Mujahid Iqbal Muhammad Shahzad Yao-qin Shen Jia-kui Li Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
description	Abstract Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it is intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that bone is a highly vascularized tissue dependent on the coordinated coupling between angiogenesis and osteogenesis, but the underlying mechanisms of bone formation and bone remodeling are poorly defined in TD chickens. Here, we observed that inhibition of vasculogenesis and angiogenesis remarkably impaired vascular invasion in the hypertrophic chondrocyte zone of the TGPs, resulting in the massive death of chondrocytes due to a shortage of blood vessels and nutrients. Moreover, the balance of the OPG (osteoprotegerin)/RANKL (receptor activator of nuclear factor-kB ligand) system is also severely disrupted during the osteogenesis process while coupling with angiogenesis, both of which eventually lead to abnormal endochondral bone formation in TD chickens. Thus, the process of vascular formation in endochondral bone appears to initiate the pathological changes in TD, and improvement of this process during coupling with osteogenesis may be a potential therapeutic approach to treat this intractable disease.
format	article
author	Shu-cheng Huang Li-hong Zhang Jia-lu Zhang Mujeeb Ur Rehman Xiao-le Tong Gang Qiu Xiong Jiang Mujahid Iqbal Muhammad Shahzad Yao-qin Shen Jia-kui Li
author_facet	Shu-cheng Huang Li-hong Zhang Jia-lu Zhang Mujeeb Ur Rehman Xiao-le Tong Gang Qiu Xiong Jiang Mujahid Iqbal Muhammad Shahzad Yao-qin Shen Jia-kui Li
author_sort	Shu-cheng Huang
title	Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
title_short	Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
title_full	Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
title_fullStr	Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
title_full_unstemmed	Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
title_sort	role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/65590ae0fbd74f21a8a34fe416468cc9
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Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens

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