A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response

The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immu...

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Autores principales:	A. Ari Hakimi, Kyrollis Attalla, Renzo G. DiNatale, Irina Ostrovnaya, Jessica Flynn, Kyle A. Blum, Yasser Ged, Douglas Hoen, Sviatoslav M. Kendall, Ed Reznik, Anita Bowman, Jason Hwee, Christopher J. Fong, Fengshen Kuo, Martin H. Voss, Timothy A. Chan, Robert J. Motzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/655ac0280dd44b29884b0203c1be1bd4
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spelling	oai:doaj.org-article:655ac0280dd44b29884b0203c1be1bd42021-12-02T17:08:46ZA pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response10.1038/s41467-020-17965-02041-1723https://doaj.org/article/655ac0280dd44b29884b0203c1be1bd42020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17965-0https://doaj.org/toc/2041-1723The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immune-checkpoint blockade.A. Ari HakimiKyrollis AttallaRenzo G. DiNataleIrina OstrovnayaJessica FlynnKyle A. BlumYasser GedDouglas HoenSviatoslav M. KendallEd ReznikAnita BowmanJason HweeChristopher J. FongFengshen KuoMartin H. VossTimothy A. ChanRobert J. MotzerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Ari Hakimi Kyrollis Attalla Renzo G. DiNatale Irina Ostrovnaya Jessica Flynn Kyle A. Blum Yasser Ged Douglas Hoen Sviatoslav M. Kendall Ed Reznik Anita Bowman Jason Hwee Christopher J. Fong Fengshen Kuo Martin H. Voss Timothy A. Chan Robert J. Motzer A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
description	The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immune-checkpoint blockade.
format	article
author	A. Ari Hakimi Kyrollis Attalla Renzo G. DiNatale Irina Ostrovnaya Jessica Flynn Kyle A. Blum Yasser Ged Douglas Hoen Sviatoslav M. Kendall Ed Reznik Anita Bowman Jason Hwee Christopher J. Fong Fengshen Kuo Martin H. Voss Timothy A. Chan Robert J. Motzer
author_facet	A. Ari Hakimi Kyrollis Attalla Renzo G. DiNatale Irina Ostrovnaya Jessica Flynn Kyle A. Blum Yasser Ged Douglas Hoen Sviatoslav M. Kendall Ed Reznik Anita Bowman Jason Hwee Christopher J. Fong Fengshen Kuo Martin H. Voss Timothy A. Chan Robert J. Motzer
author_sort	A. Ari Hakimi
title	A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_short	A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_full	A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_fullStr	A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_full_unstemmed	A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_sort	pan-cancer analysis of pbaf complex mutations and their association with immunotherapy response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/655ac0280dd44b29884b0203c1be1bd4
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A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response

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