Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy

Trastuzumab binding to tumor cells depends on the availability of HER2 at the cell membrane. Here the authors show that caveolin-1 (CAV1) regulates HER2 density at the cell membranes and that CAV1 gene knockdown or protein depletion via the cholesterol modulator lovastatin, increases trastuzumab bin...

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Autores principales:	Patrícia M. R. Pereira, Sai Kiran Sharma, Lukas M. Carter, Kimberly J. Edwards, Jacob Pourat, Ashwin Ragupathi, Yelena Y. Janjigian, Jeremy C. Durack, Jason S. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/655bc247cda34be5801b730bd0910363
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spelling	oai:doaj.org-article:655bc247cda34be5801b730bd09103632021-12-02T17:31:43ZCaveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy10.1038/s41467-018-07608-w2041-1723https://doaj.org/article/655bc247cda34be5801b730bd09103632018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07608-whttps://doaj.org/toc/2041-1723Trastuzumab binding to tumor cells depends on the availability of HER2 at the cell membrane. Here the authors show that caveolin-1 (CAV1) regulates HER2 density at the cell membranes and that CAV1 gene knockdown or protein depletion via the cholesterol modulator lovastatin, increases trastuzumab binding and anti-tumor activity.Patrícia M. R. PereiraSai Kiran SharmaLukas M. CarterKimberly J. EdwardsJacob PouratAshwin RagupathiYelena Y. JanjigianJeremy C. DurackJason S. LewisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrícia M. R. Pereira Sai Kiran Sharma Lukas M. Carter Kimberly J. Edwards Jacob Pourat Ashwin Ragupathi Yelena Y. Janjigian Jeremy C. Durack Jason S. Lewis Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
description	Trastuzumab binding to tumor cells depends on the availability of HER2 at the cell membrane. Here the authors show that caveolin-1 (CAV1) regulates HER2 density at the cell membranes and that CAV1 gene knockdown or protein depletion via the cholesterol modulator lovastatin, increases trastuzumab binding and anti-tumor activity.
format	article
author	Patrícia M. R. Pereira Sai Kiran Sharma Lukas M. Carter Kimberly J. Edwards Jacob Pourat Ashwin Ragupathi Yelena Y. Janjigian Jeremy C. Durack Jason S. Lewis
author_facet	Patrícia M. R. Pereira Sai Kiran Sharma Lukas M. Carter Kimberly J. Edwards Jacob Pourat Ashwin Ragupathi Yelena Y. Janjigian Jeremy C. Durack Jason S. Lewis
author_sort	Patrícia M. R. Pereira
title	Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
title_short	Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
title_full	Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
title_fullStr	Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
title_full_unstemmed	Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
title_sort	caveolin-1 mediates cellular distribution of her2 and affects trastuzumab binding and therapeutic efficacy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/655bc247cda34be5801b730bd0910363
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Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy

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