Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different functional states.

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Autores principales:	Dorothy D. Majewski, Liam J. Worrall, Chuan Hong, Claire E. Atkinson, Marija Vuckovic, Nobuhiko Watanabe, Zhiheng Yu, Natalie C. J. Strynadka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/655ed92072524851b04d71448b77be1e
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spelling	oai:doaj.org-article:655ed92072524851b04d71448b77be1e2021-12-02T14:39:02ZCryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry10.1038/s41467-019-08477-72041-1723https://doaj.org/article/655ed92072524851b04d71448b77be1e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08477-7https://doaj.org/toc/2041-1723Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different functional states.Dorothy D. MajewskiLiam J. WorrallChuan HongClaire E. AtkinsonMarija VuckovicNobuhiko WatanabeZhiheng YuNatalie C. J. StrynadkaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dorothy D. Majewski Liam J. Worrall Chuan Hong Claire E. Atkinson Marija Vuckovic Nobuhiko Watanabe Zhiheng Yu Natalie C. J. Strynadka Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
description	Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different functional states.
format	article
author	Dorothy D. Majewski Liam J. Worrall Chuan Hong Claire E. Atkinson Marija Vuckovic Nobuhiko Watanabe Zhiheng Yu Natalie C. J. Strynadka
author_facet	Dorothy D. Majewski Liam J. Worrall Chuan Hong Claire E. Atkinson Marija Vuckovic Nobuhiko Watanabe Zhiheng Yu Natalie C. J. Strynadka
author_sort	Dorothy D. Majewski
title	Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
title_short	Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
title_full	Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
title_fullStr	Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
title_full_unstemmed	Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
title_sort	cryo-em structure of the homohexameric t3ss atpase-central stalk complex reveals rotary atpase-like asymmetry
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/655ed92072524851b04d71448b77be1e
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Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

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