Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents

A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evalua...

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Autores principales:	Iryna Myrko, Taras Chaban, Vasyl Matiychuk
Formato:	article
Lenguaje:	EN
Publicado:	Growing Science 2022
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6562aee562714044b33c4dd36b89b39d
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spelling	oai:doaj.org-article:6562aee562714044b33c4dd36b89b39d2021-11-12T12:52:42ZSynthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents1927-72961927-730X10.5267/j.ccl.2021.9.003https://doaj.org/article/6562aee562714044b33c4dd36b89b39d2022-01-01T00:00:00Zhttp://www.growingscience.com/ccl/Vol11/ccl_2021_34.pdfhttps://doaj.org/toc/1927-7296https://doaj.org/toc/1927-730X A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.Iryna MyrkoTaras ChabanVasyl MatiychukGrowing SciencearticleChemistryQD1-999ENCurrent Chemistry Letters, Vol 11, Iss 1, Pp 75-82 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Iryna Myrko Taras Chaban Vasyl Matiychuk Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
description	A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.
format	article
author	Iryna Myrko Taras Chaban Vasyl Matiychuk
author_facet	Iryna Myrko Taras Chaban Vasyl Matiychuk
author_sort	Iryna Myrko
title	Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
title_short	Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
title_full	Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
title_fullStr	Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
title_full_unstemmed	Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
title_sort	synthesis and biological evaluation of some new 7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
publisher	Growing Science
publishDate	2022
url	https://doaj.org/article/6562aee562714044b33c4dd36b89b39d
work_keys_str_mv	AT irynamyrko synthesisandbiologicalevaluationofsomenew7h124triazolo34b134thiadiazinesasantimicrobialagents AT taraschaban synthesisandbiologicalevaluationofsomenew7h124triazolo34b134thiadiazinesasantimicrobialagents AT vasylmatiychuk synthesisandbiologicalevaluationofsomenew7h124triazolo34b134thiadiazinesasantimicrobialagents
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Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents

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