A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to...
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Nature Portfolio
2017
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oai:doaj.org-article:6564fe588369406e87c0d1e279e7b8c42021-12-02T14:41:09ZA comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family10.1038/s41467-017-01642-w2041-1723https://doaj.org/article/6564fe588369406e87c0d1e279e7b8c42017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01642-whttps://doaj.org/toc/2041-1723The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to address their functional inter-relationships.Jordi Carreras-PuigvertMarinka ZitnikAnn-Sofie JemthMegan CarterJudith E. UnterlassBjörn HallströmOlga LosevaZhir KaremJosé Manuel Calderón-MontañoCecilia LindskogPer-Henrik EdqvistDamian J. MatuszewskiHammou Ait BlalRonnie P. A. BerntssonMaria HäggbladUlf MartensMatthew StudhamBo LundgrenCarolina WählbyErik L. L. SonnhammerEmma LundbergPål StenmarkBlaz ZupanThomas HelledayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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Science Q Jordi Carreras-Puigvert Marinka Zitnik Ann-Sofie Jemth Megan Carter Judith E. Unterlass Björn Hallström Olga Loseva Zhir Karem José Manuel Calderón-Montaño Cecilia Lindskog Per-Henrik Edqvist Damian J. Matuszewski Hammou Ait Blal Ronnie P. A. Berntsson Maria Häggblad Ulf Martens Matthew Studham Bo Lundgren Carolina Wählby Erik L. L. Sonnhammer Emma Lundberg Pål Stenmark Blaz Zupan Thomas Helleday A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| description |
The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to address their functional inter-relationships. |
| format |
article |
| author |
Jordi Carreras-Puigvert Marinka Zitnik Ann-Sofie Jemth Megan Carter Judith E. Unterlass Björn Hallström Olga Loseva Zhir Karem José Manuel Calderón-Montaño Cecilia Lindskog Per-Henrik Edqvist Damian J. Matuszewski Hammou Ait Blal Ronnie P. A. Berntsson Maria Häggblad Ulf Martens Matthew Studham Bo Lundgren Carolina Wählby Erik L. L. Sonnhammer Emma Lundberg Pål Stenmark Blaz Zupan Thomas Helleday |
| author_facet |
Jordi Carreras-Puigvert Marinka Zitnik Ann-Sofie Jemth Megan Carter Judith E. Unterlass Björn Hallström Olga Loseva Zhir Karem José Manuel Calderón-Montaño Cecilia Lindskog Per-Henrik Edqvist Damian J. Matuszewski Hammou Ait Blal Ronnie P. A. Berntsson Maria Häggblad Ulf Martens Matthew Studham Bo Lundgren Carolina Wählby Erik L. L. Sonnhammer Emma Lundberg Pål Stenmark Blaz Zupan Thomas Helleday |
| author_sort |
Jordi Carreras-Puigvert |
| title |
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| title_short |
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| title_full |
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| title_fullStr |
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| title_full_unstemmed |
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family |
| title_sort |
comprehensive structural, biochemical and biological profiling of the human nudix hydrolase family |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6564fe588369406e87c0d1e279e7b8c4 |
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