Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins

Abstract In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were incl...

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Autores principales:	Dongying Zhao, Lile Zou, Xiaoping Lei, Yongjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65650f815fb642ea85555a4446e514d2
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spelling	oai:doaj.org-article:65650f815fb642ea85555a4446e514d22021-12-02T16:07:01ZGender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins10.1038/s41598-017-08951-62045-2322https://doaj.org/article/65650f815fb642ea85555a4446e514d22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08951-6https://doaj.org/toc/2045-2322Abstract In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were included in this analysis. Among the mixed-gender twins, no significant difference in the odds of fetal mortality between male twins (1.05%) and female co-twins (1.04%). However, male twins were at increased odds of neonatal mortality (adjusted OR 1.59; 95% CI 1.37, 1.85) and overall infant mortality (adjusted OR 1.43; 95% CI 1.27, 1.61) relative to their female co-twins. Congenital abnormalities (adjusted OR 1.38; 95% CI 1.27, 1.50) were identified significantly more frequently in male than female twins. Moreover, increased odds of having low 5-minute Apgar score (<7) (adjusted OR 1.15; 95% CI 1.05, 1.26), assistant ventilation >30 minutes (adjusted OR 1.31; 95% CI 1.17, 1.47), and respiratory distress syndrome (adjusted OR 1.45; 95% CI 1.26, 1.66) were identified in male twins relative to their female counterparts. The results of our study indicated that in mixed-gender twin pairs, the odds of infant mortality and neonatal morbidity were higher in male twins than their female co-twins.Dongying ZhaoLile ZouXiaoping LeiYongjun ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongying Zhao Lile Zou Xiaoping Lei Yongjun Zhang Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
description	Abstract In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were included in this analysis. Among the mixed-gender twins, no significant difference in the odds of fetal mortality between male twins (1.05%) and female co-twins (1.04%). However, male twins were at increased odds of neonatal mortality (adjusted OR 1.59; 95% CI 1.37, 1.85) and overall infant mortality (adjusted OR 1.43; 95% CI 1.27, 1.61) relative to their female co-twins. Congenital abnormalities (adjusted OR 1.38; 95% CI 1.27, 1.50) were identified significantly more frequently in male than female twins. Moreover, increased odds of having low 5-minute Apgar score (<7) (adjusted OR 1.15; 95% CI 1.05, 1.26), assistant ventilation >30 minutes (adjusted OR 1.31; 95% CI 1.17, 1.47), and respiratory distress syndrome (adjusted OR 1.45; 95% CI 1.26, 1.66) were identified in male twins relative to their female counterparts. The results of our study indicated that in mixed-gender twin pairs, the odds of infant mortality and neonatal morbidity were higher in male twins than their female co-twins.
format	article
author	Dongying Zhao Lile Zou Xiaoping Lei Yongjun Zhang
author_facet	Dongying Zhao Lile Zou Xiaoping Lei Yongjun Zhang
author_sort	Dongying Zhao
title	Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
title_short	Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
title_full	Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
title_fullStr	Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
title_full_unstemmed	Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins
title_sort	gender differences in infant mortality and neonatal morbidity in mixed-gender twins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65650f815fb642ea85555a4446e514d2
work_keys_str_mv	AT dongyingzhao genderdifferencesininfantmortalityandneonatalmorbidityinmixedgendertwins AT lilezou genderdifferencesininfantmortalityandneonatalmorbidityinmixedgendertwins AT xiaopinglei genderdifferencesininfantmortalityandneonatalmorbidityinmixedgendertwins AT yongjunzhang genderdifferencesininfantmortalityandneonatalmorbidityinmixedgendertwins
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Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins

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