An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli

Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chunhui Miao, Mingyu Yu, Geng Pei, Zhenyi Ma, Lisong Zhang, Jianming Yang, Junqiang Lv, Zhi-Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6566a1096e0b4b0b8b6e482feb14534a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6566a1096e0b4b0b8b6e482feb14534a
record_format	dspace
spelling	oai:doaj.org-article:6566a1096e0b4b0b8b6e482feb14534a2021-12-02T14:35:38ZAn infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli10.1038/s41467-021-22726-82041-1723https://doaj.org/article/6566a1096e0b4b0b8b6e482feb14534a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22726-8https://doaj.org/toc/2041-1723Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.Chunhui MiaoMingyu YuGeng PeiZhenyi MaLisong ZhangJianming YangJunqiang LvZhi-Song ZhangEvan T. KellerZhi YaoQuan WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunhui Miao Mingyu Yu Geng Pei Zhenyi Ma Lisong Zhang Jianming Yang Junqiang Lv Zhi-Song Zhang Evan T. Keller Zhi Yao Quan Wang An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
description	Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.
format	article
author	Chunhui Miao Mingyu Yu Geng Pei Zhenyi Ma Lisong Zhang Jianming Yang Junqiang Lv Zhi-Song Zhang Evan T. Keller Zhi Yao Quan Wang
author_facet	Chunhui Miao Mingyu Yu Geng Pei Zhenyi Ma Lisong Zhang Jianming Yang Junqiang Lv Zhi-Song Zhang Evan T. Keller Zhi Yao Quan Wang
author_sort	Chunhui Miao
title	An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
title_short	An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
title_full	An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
title_fullStr	An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
title_full_unstemmed	An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
title_sort	infection-induced rhob-beclin 1-hsp90 complex enhances clearance of uropathogenic escherichia coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6566a1096e0b4b0b8b6e482feb14534a
work_keys_str_mv	AT chunhuimiao aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT mingyuyu aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT gengpei aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhenyima aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT lisongzhang aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT jianmingyang aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT junqianglv aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhisongzhang aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT evantkeller aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhiyao aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT quanwang aninfectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT chunhuimiao infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT mingyuyu infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT gengpei infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhenyima infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT lisongzhang infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT jianmingyang infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT junqianglv infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhisongzhang infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT evantkeller infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT zhiyao infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli AT quanwang infectioninducedrhobbeclin1hsp90complexenhancesclearanceofuropathogenicescherichiacoli
_version_	1718391076589404160

An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli

Ejemplares similares