Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Abstract We aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD−) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+. We retrospec...

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Autores principales:	Qiaozhu Zeng, Jingyuan Gao, Xinyu Zhang, Aichun Liu, Zhenfan Wang, Ziqiao Wang, Xiying Chi, Qianyu Shi, Yi Wang, Fei Yang, Yanying Liu, Zhan-Guo Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/656a3d6e81b547e7a04f45d04fbb5c31
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spelling	oai:doaj.org-article:656a3d6e81b547e7a04f45d04fbb5c312021-12-02T15:45:27ZDisparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients10.1038/s41598-021-89844-72045-2322https://doaj.org/article/656a3d6e81b547e7a04f45d04fbb5c312021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89844-7https://doaj.org/toc/2045-2322Abstract We aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD−) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+. We retrospectively analyzed the medical records of 470 IgG4-related disease (IgG4-RD) patients at Peking University People’s Hospital from January 2004 to January 2020. The demographic, clinical, laboratory, radiological and pathological characteristics between IgG4-RKD+ and IgG4-RKD− were compared. Twenty IgG4-RD patients who had definite etiology of renal impairment including diabetes, hypertension and etc. were excluded. Among the remained 450 IgG4-RD patients, 53 were diagnosed with IgG4-RKD+ . IgG4-RKD+ patients had older age at onset and at diagnosis. Male to female ratio of IgG4-RKD+ patients is significantly higher. In the IgG4-RKD+ group, the most commonly involved organs were salivary gland, lymph nodes and pancreas. It was found that renal function was impaired in approximately 40% of IgG4-RKD+ patients. The most common imaging finding is multiple, often bilateral, hypodense lesions. Male sex, more than three organs involved, and low serum C3 level were risk factors for IgG4-RKD+ in IgG4-RD patients. These findings indicate potential differences in pathogenesis of these two phenotypes.Qiaozhu ZengJingyuan GaoXinyu ZhangAichun LiuZhenfan WangZiqiao WangXiying ChiQianyu ShiYi WangFei YangYanying LiuZhan-Guo LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiaozhu Zeng Jingyuan Gao Xinyu Zhang Aichun Liu Zhenfan Wang Ziqiao Wang Xiying Chi Qianyu Shi Yi Wang Fei Yang Yanying Liu Zhan-Guo Li Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
description	Abstract We aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD−) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+. We retrospectively analyzed the medical records of 470 IgG4-related disease (IgG4-RD) patients at Peking University People’s Hospital from January 2004 to January 2020. The demographic, clinical, laboratory, radiological and pathological characteristics between IgG4-RKD+ and IgG4-RKD− were compared. Twenty IgG4-RD patients who had definite etiology of renal impairment including diabetes, hypertension and etc. were excluded. Among the remained 450 IgG4-RD patients, 53 were diagnosed with IgG4-RKD+ . IgG4-RKD+ patients had older age at onset and at diagnosis. Male to female ratio of IgG4-RKD+ patients is significantly higher. In the IgG4-RKD+ group, the most commonly involved organs were salivary gland, lymph nodes and pancreas. It was found that renal function was impaired in approximately 40% of IgG4-RKD+ patients. The most common imaging finding is multiple, often bilateral, hypodense lesions. Male sex, more than three organs involved, and low serum C3 level were risk factors for IgG4-RKD+ in IgG4-RD patients. These findings indicate potential differences in pathogenesis of these two phenotypes.
format	article
author	Qiaozhu Zeng Jingyuan Gao Xinyu Zhang Aichun Liu Zhenfan Wang Ziqiao Wang Xiying Chi Qianyu Shi Yi Wang Fei Yang Yanying Liu Zhan-Guo Li
author_facet	Qiaozhu Zeng Jingyuan Gao Xinyu Zhang Aichun Liu Zhenfan Wang Ziqiao Wang Xiying Chi Qianyu Shi Yi Wang Fei Yang Yanying Liu Zhan-Guo Li
author_sort	Qiaozhu Zeng
title	Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
title_short	Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
title_full	Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
title_fullStr	Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
title_full_unstemmed	Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients
title_sort	disparities between igg4-related kidney disease and extrarenal igg4-related disease in a case–control study based on 450 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/656a3d6e81b547e7a04f45d04fbb5c31
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Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

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