HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while preserving cytochrome c oxidase activity.
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Nature Portfolio
2016
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oai:doaj.org-article:656cb902beff4390965095a7899b983e2021-12-02T16:50:56ZHIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity10.1038/ncomms116352041-1723https://doaj.org/article/656cb902beff4390965095a7899b983e2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11635https://doaj.org/toc/2041-1723Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while preserving cytochrome c oxidase activity.Hiroaki SembaNorihiko TakedaTakayuki IsagawaYuki SugiuraKurara HondaMasaki WakeHidenobu MiyazawaYoshifumi YamaguchiMasayuki MiuraDana M. R. JenkinsHyunsung ChoiJung-whan KimMasataka AsagiriAndrew S. CowburnHajime AbeKatsura SomaKatsuhiro KoyamaManami KatohKeimon SayamaNobuhito GodaRandall S. JohnsonIchiro ManabeRyozo NagaiIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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| topic |
Science Q |
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Science Q Hiroaki Semba Norihiko Takeda Takayuki Isagawa Yuki Sugiura Kurara Honda Masaki Wake Hidenobu Miyazawa Yoshifumi Yamaguchi Masayuki Miura Dana M. R. Jenkins Hyunsung Choi Jung-whan Kim Masataka Asagiri Andrew S. Cowburn Hajime Abe Katsura Soma Katsuhiro Koyama Manami Katoh Keimon Sayama Nobuhito Goda Randall S. Johnson Ichiro Manabe Ryozo Nagai Issei Komuro HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| description |
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while preserving cytochrome c oxidase activity. |
| format |
article |
| author |
Hiroaki Semba Norihiko Takeda Takayuki Isagawa Yuki Sugiura Kurara Honda Masaki Wake Hidenobu Miyazawa Yoshifumi Yamaguchi Masayuki Miura Dana M. R. Jenkins Hyunsung Choi Jung-whan Kim Masataka Asagiri Andrew S. Cowburn Hajime Abe Katsura Soma Katsuhiro Koyama Manami Katoh Keimon Sayama Nobuhito Goda Randall S. Johnson Ichiro Manabe Ryozo Nagai Issei Komuro |
| author_facet |
Hiroaki Semba Norihiko Takeda Takayuki Isagawa Yuki Sugiura Kurara Honda Masaki Wake Hidenobu Miyazawa Yoshifumi Yamaguchi Masayuki Miura Dana M. R. Jenkins Hyunsung Choi Jung-whan Kim Masataka Asagiri Andrew S. Cowburn Hajime Abe Katsura Soma Katsuhiro Koyama Manami Katoh Keimon Sayama Nobuhito Goda Randall S. Johnson Ichiro Manabe Ryozo Nagai Issei Komuro |
| author_sort |
Hiroaki Semba |
| title |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| title_short |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| title_full |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| title_fullStr |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| title_full_unstemmed |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| title_sort |
hif-1α-pdk1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/656cb902beff4390965095a7899b983e |
| work_keys_str_mv |
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