Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.

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Autores principales: Ippei Kikuchi, Atsushi Takahashi-Kanemitsu, Natsuki Sakiyama, Chao Tang, Pei-Jung Tang, Saori Noda, Kazuki Nakao, Hidetoshi Kassai, Toshiro Sato, Atsu Aiba, Masanori Hatakeyama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/656e488c9d224fa48eaa402ec5de0911
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spelling oai:doaj.org-article:656e488c9d224fa48eaa402ec5de09112021-12-02T16:49:43ZDephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways10.1038/ncomms128872041-1723https://doaj.org/article/656e488c9d224fa48eaa402ec5de09112016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12887https://doaj.org/toc/2041-1723Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.Ippei KikuchiAtsushi Takahashi-KanemitsuNatsuki SakiyamaChao TangPei-Jung TangSaori NodaKazuki NakaoHidetoshi KassaiToshiro SatoAtsu AibaMasanori HatakeyamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ippei Kikuchi
Atsushi Takahashi-Kanemitsu
Natsuki Sakiyama
Chao Tang
Pei-Jung Tang
Saori Noda
Kazuki Nakao
Hidetoshi Kassai
Toshiro Sato
Atsu Aiba
Masanori Hatakeyama
Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
description Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.
format article
author Ippei Kikuchi
Atsushi Takahashi-Kanemitsu
Natsuki Sakiyama
Chao Tang
Pei-Jung Tang
Saori Noda
Kazuki Nakao
Hidetoshi Kassai
Toshiro Sato
Atsu Aiba
Masanori Hatakeyama
author_facet Ippei Kikuchi
Atsushi Takahashi-Kanemitsu
Natsuki Sakiyama
Chao Tang
Pei-Jung Tang
Saori Noda
Kazuki Nakao
Hidetoshi Kassai
Toshiro Sato
Atsu Aiba
Masanori Hatakeyama
author_sort Ippei Kikuchi
title Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
title_short Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
title_full Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
title_fullStr Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
title_full_unstemmed Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
title_sort dephosphorylated parafibromin is a transcriptional coactivator of the wnt/hedgehog/notch pathways
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/656e488c9d224fa48eaa402ec5de0911
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