Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography

No study has examined myocardial work in subjects with cancer therapy-related cardiac dysfunction (CTRCD). Myocardial work, as a new ultrasonic indicator, reflects the metabolism and oxygen consumption of the left ventricle. The aim of this study was to test the relative value of new indices of myoc...

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Autores principales:	Jingyuan Guan, Wuyun Bao, Yao Xu, Wei Yang, Mengmeng Li, Mingjun Xu, Yu Zhang, Mei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anthracycline trastuzumab cardiotoxicity speckle tracking technology myocardial work Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/657455c109134643987eac244b8b1036
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spelling	oai:doaj.org-article:657455c109134643987eac244b8b10362021-11-11T06:50:34ZAssessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography1663-981210.3389/fphar.2021.770580https://doaj.org/article/657455c109134643987eac244b8b10362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.770580/fullhttps://doaj.org/toc/1663-9812No study has examined myocardial work in subjects with cancer therapy-related cardiac dysfunction (CTRCD). Myocardial work, as a new ultrasonic indicator, reflects the metabolism and oxygen consumption of the left ventricle. The aim of this study was to test the relative value of new indices of myocardial work and global longitudinal strain (GLS) in detecting changes in myocardial function during the treatment of breast cancer by two-dimensional and three-dimensional echocardiography. We enrolled 79 breast cancer patients undergoing different tumor treatment regimens. Follow-up observation was conducted before and after chemotherapy. The effects of breast cancer chemotherapy and targeted therapy on the development of CTRCD [defined as an absolute reduction in left ventricular ejection fraction (LVEF) of >5% to <53%] were detected by two-dimensional and three-dimensional speckle tracking echocardiography. Our findings further indicate that LVEF, myocardial work index (GWI) and myocardial work efficiency (GWE) showed significant changes after the T6 cycle, and GLS showed significant changes after the T4 cycle (p < 0.05). The three-dimensional strain changes after T6 and T8 had no advantages compared with GLS. Body mass index (BMI), the GLS change rate after the second cycle of chemotherapy (G2v) and the 3D-GCS change rate after the second cycle of chemotherapy (C2v) were independent factors that could predict the occurrence of CTRCD during follow-up, among which BMI was the best predictor (area under the curve, 0.922). In conclusion, the current study determined that GLS was superior to GWI in predicting cardiac function in patients with tumors with little variation in blood pressure. BMI, G2v and C2v can be used to predict the occurrence of CTRCD.Jingyuan GuanWuyun BaoYao XuWei YangMengmeng LiMingjun XuYu ZhangMei ZhangFrontiers Media S.A.articleanthracyclinetrastuzumabcardiotoxicityspeckle tracking technologymyocardial workTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anthracycline trastuzumab cardiotoxicity speckle tracking technology myocardial work Therapeutics. Pharmacology RM1-950
spellingShingle	anthracycline trastuzumab cardiotoxicity speckle tracking technology myocardial work Therapeutics. Pharmacology RM1-950 Jingyuan Guan Wuyun Bao Yao Xu Wei Yang Mengmeng Li Mingjun Xu Yu Zhang Mei Zhang Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
description	No study has examined myocardial work in subjects with cancer therapy-related cardiac dysfunction (CTRCD). Myocardial work, as a new ultrasonic indicator, reflects the metabolism and oxygen consumption of the left ventricle. The aim of this study was to test the relative value of new indices of myocardial work and global longitudinal strain (GLS) in detecting changes in myocardial function during the treatment of breast cancer by two-dimensional and three-dimensional echocardiography. We enrolled 79 breast cancer patients undergoing different tumor treatment regimens. Follow-up observation was conducted before and after chemotherapy. The effects of breast cancer chemotherapy and targeted therapy on the development of CTRCD [defined as an absolute reduction in left ventricular ejection fraction (LVEF) of >5% to <53%] were detected by two-dimensional and three-dimensional speckle tracking echocardiography. Our findings further indicate that LVEF, myocardial work index (GWI) and myocardial work efficiency (GWE) showed significant changes after the T6 cycle, and GLS showed significant changes after the T4 cycle (p < 0.05). The three-dimensional strain changes after T6 and T8 had no advantages compared with GLS. Body mass index (BMI), the GLS change rate after the second cycle of chemotherapy (G2v) and the 3D-GCS change rate after the second cycle of chemotherapy (C2v) were independent factors that could predict the occurrence of CTRCD during follow-up, among which BMI was the best predictor (area under the curve, 0.922). In conclusion, the current study determined that GLS was superior to GWI in predicting cardiac function in patients with tumors with little variation in blood pressure. BMI, G2v and C2v can be used to predict the occurrence of CTRCD.
format	article
author	Jingyuan Guan Wuyun Bao Yao Xu Wei Yang Mengmeng Li Mingjun Xu Yu Zhang Mei Zhang
author_facet	Jingyuan Guan Wuyun Bao Yao Xu Wei Yang Mengmeng Li Mingjun Xu Yu Zhang Mei Zhang
author_sort	Jingyuan Guan
title	Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
title_short	Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
title_full	Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
title_fullStr	Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
title_full_unstemmed	Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography
title_sort	assessment of myocardial work in cancer therapy-related cardiac dysfunction and analysis of ctrcd prediction by echocardiography
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/657455c109134643987eac244b8b1036
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Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography

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