Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age

Justine Cormier, Catherine J ChuMassachusetts General Hospital, Department of Neurology, Programs in Child Neurology and Neurophysiology, Boston, MA, USAAbstract: Epilepsy is a common neurological disorder in the pediatric population, affecting up to one percent of children, and for which the mainst...

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Autores principales:	Cormier J, Chu CJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/65754c44c3b84d56ae57f5fe855b3988
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spelling	oai:doaj.org-article:65754c44c3b84d56ae57f5fe855b39882021-12-02T07:06:53ZSafety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age1176-63281178-2021https://doaj.org/article/65754c44c3b84d56ae57f5fe855b39882013-02-01T00:00:00Zhttp://www.dovepress.com/safety-and-efficacy-of-levetiracetam-for-the-treatment-of-partial-onse-a12277https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Justine Cormier, Catherine J ChuMassachusetts General Hospital, Department of Neurology, Programs in Child Neurology and Neurophysiology, Boston, MA, USAAbstract: Epilepsy is a common neurological disorder in the pediatric population, affecting up to one percent of children, and for which the mainstay of treatment is anticonvulsant medication. Despite the frequent use of anticonvulsant drugs, remarkably little is known about the safety and efficacy of most of these medications in the pediatric epilepsy population. Of 34 anticonvulsants currently approved for use by the US Food and Drug Administration (FDA), only 13 have been approved for use in children. Although infants and young children are disproportionately affected by epilepsy, there are currently only three anticonvulsant medications that have been specifically evaluated and approved for use in children younger than 2 years of age. In 2012, the FDA approved levetiracetam as an adjunctive treatment for partial onset seizures in infants and children from one month of age. Here we review the available data on levetiracetam in the pediatric epilepsy population. We first discuss the pharmacological profile of levetiracetam, including its mechanism of action, formulations and dosing, and pharmacokinetics in children. We then review the available efficacy, safety, and tolerability data in children from one month of age with partial onset seizures. We conclude that the current data leading to the approval of levetiracetam for use in infants and children with partial onset seizures is encouraging, although more work needs to be done before definitive conclusions can be drawn about the efficacy of levetiracetam across different pediatric age groups.Keywords: levetiracetam, anticonvulsant drug, partial seizures, pediatric epilepsyCormier JChu CJDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 295-306 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cormier J Chu CJ Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
description	Justine Cormier, Catherine J ChuMassachusetts General Hospital, Department of Neurology, Programs in Child Neurology and Neurophysiology, Boston, MA, USAAbstract: Epilepsy is a common neurological disorder in the pediatric population, affecting up to one percent of children, and for which the mainstay of treatment is anticonvulsant medication. Despite the frequent use of anticonvulsant drugs, remarkably little is known about the safety and efficacy of most of these medications in the pediatric epilepsy population. Of 34 anticonvulsants currently approved for use by the US Food and Drug Administration (FDA), only 13 have been approved for use in children. Although infants and young children are disproportionately affected by epilepsy, there are currently only three anticonvulsant medications that have been specifically evaluated and approved for use in children younger than 2 years of age. In 2012, the FDA approved levetiracetam as an adjunctive treatment for partial onset seizures in infants and children from one month of age. Here we review the available data on levetiracetam in the pediatric epilepsy population. We first discuss the pharmacological profile of levetiracetam, including its mechanism of action, formulations and dosing, and pharmacokinetics in children. We then review the available efficacy, safety, and tolerability data in children from one month of age with partial onset seizures. We conclude that the current data leading to the approval of levetiracetam for use in infants and children with partial onset seizures is encouraging, although more work needs to be done before definitive conclusions can be drawn about the efficacy of levetiracetam across different pediatric age groups.Keywords: levetiracetam, anticonvulsant drug, partial seizures, pediatric epilepsy
format	article
author	Cormier J Chu CJ
author_facet	Cormier J Chu CJ
author_sort	Cormier J
title	Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
title_short	Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
title_full	Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
title_fullStr	Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
title_full_unstemmed	Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
title_sort	safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/65754c44c3b84d56ae57f5fe855b3988
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Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age

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