Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo

Post transcriptional modification of RNAs represents an important layer of gene regulation. Here the authors describe NAIL-MS—a method for monoisotopic RNA labeling in cell culture—demonstrating its capabilities by analyzing the modification kinetics of total tRNA, 18S rRNA and tRNAPhe as models....

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Autores principales: Matthias Heiss, Felix Hagelskamp, Virginie Marchand, Yuri Motorin, Stefanie Kellner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6576875b198b477bb54b337f7ff87c65
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