Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.

Kaposi sarcoma (KS) is an AIDS-defining angio-proliferative malignancy highly prevalent in Sub-Saharan Africa. The main objective of this study was to determine the factors associated with recurrence of HIV-associated KS. We recruited a cohort of individuals on antiretroviral therapy who were in rem...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Owen Ngalamika, Marie Claire Mukasine, Musonda Kawimbe, Faheema Vally
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/657b92a55b204b2cb6c6c82b7ec03bb6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:657b92a55b204b2cb6c6c82b7ec03bb6
record_format	dspace
spelling	oai:doaj.org-article:657b92a55b204b2cb6c6c82b7ec03bb62021-12-02T20:15:39ZViral and immunological markers of HIV-associated Kaposi sarcoma recurrence.1932-620310.1371/journal.pone.0254177https://doaj.org/article/657b92a55b204b2cb6c6c82b7ec03bb62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254177https://doaj.org/toc/1932-6203Kaposi sarcoma (KS) is an AIDS-defining angio-proliferative malignancy highly prevalent in Sub-Saharan Africa. The main objective of this study was to determine the factors associated with recurrence of HIV-associated KS. We recruited a cohort of individuals on antiretroviral therapy who were in remission for HIV-associated KS after undergoing cytotoxic cancer chemotherapy. Collected variables included sociodemographic and clinical parameters, cytokines and chemokines, HIV viral loads, and CD4 counts. Compared to individuals who had KS recurrence, IL-5 was significantly higher at time of follow-up in individuals who had sustained remission (22.7pg/ml vs. 2.4pg/ml; p = 0.02); IL-6 was significantly higher at baseline and time of follow-up in individuals who had sustained remission, (18.4pg/ml vs. 0pg/ml; p = 0.01) and (18.0pg/ml vs. 0.18pg/ml; p = 0.03) respectively; IP-10 was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (534pg/ml vs. 920pg/ml; p = 0.04) and (446pg/ml vs.1098pg/ml; p = 0.01) respectively; while HIV viral load was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (0copies/ml vs. 113copies/ml; p = 0.004) and (0copies/ml vs. 152copies/ml; p = 0.025) respectively. Plasma levels of IL-5, IL-6, and IP-10 are associated with recurrence of HIV-associated KS, while persistently detectable HIV viral loads increase the risk of KS recurrence.Owen NgalamikaMarie Claire MukasineMusonda KawimbeFaheema VallyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Owen Ngalamika Marie Claire Mukasine Musonda Kawimbe Faheema Vally Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
description	Kaposi sarcoma (KS) is an AIDS-defining angio-proliferative malignancy highly prevalent in Sub-Saharan Africa. The main objective of this study was to determine the factors associated with recurrence of HIV-associated KS. We recruited a cohort of individuals on antiretroviral therapy who were in remission for HIV-associated KS after undergoing cytotoxic cancer chemotherapy. Collected variables included sociodemographic and clinical parameters, cytokines and chemokines, HIV viral loads, and CD4 counts. Compared to individuals who had KS recurrence, IL-5 was significantly higher at time of follow-up in individuals who had sustained remission (22.7pg/ml vs. 2.4pg/ml; p = 0.02); IL-6 was significantly higher at baseline and time of follow-up in individuals who had sustained remission, (18.4pg/ml vs. 0pg/ml; p = 0.01) and (18.0pg/ml vs. 0.18pg/ml; p = 0.03) respectively; IP-10 was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (534pg/ml vs. 920pg/ml; p = 0.04) and (446pg/ml vs.1098pg/ml; p = 0.01) respectively; while HIV viral load was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (0copies/ml vs. 113copies/ml; p = 0.004) and (0copies/ml vs. 152copies/ml; p = 0.025) respectively. Plasma levels of IL-5, IL-6, and IP-10 are associated with recurrence of HIV-associated KS, while persistently detectable HIV viral loads increase the risk of KS recurrence.
format	article
author	Owen Ngalamika Marie Claire Mukasine Musonda Kawimbe Faheema Vally
author_facet	Owen Ngalamika Marie Claire Mukasine Musonda Kawimbe Faheema Vally
author_sort	Owen Ngalamika
title	Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
title_short	Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
title_full	Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
title_fullStr	Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
title_full_unstemmed	Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
title_sort	viral and immunological markers of hiv-associated kaposi sarcoma recurrence.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/657b92a55b204b2cb6c6c82b7ec03bb6
work_keys_str_mv	AT owenngalamika viralandimmunologicalmarkersofhivassociatedkaposisarcomarecurrence AT marieclairemukasine viralandimmunologicalmarkersofhivassociatedkaposisarcomarecurrence AT musondakawimbe viralandimmunologicalmarkersofhivassociatedkaposisarcomarecurrence AT faheemavally viralandimmunologicalmarkersofhivassociatedkaposisarcomarecurrence
_version_	1718374529545273344

Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.

Ejemplares similares