Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-gate in an open conformation and discuss mech...

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Autores principales:	Shin-Fu Chen, Nan-Lan Huang, Jung-Hsin Lin, Chyuan-Chuan Wu, Ying-Ren Wang, Yu-Jen Yu, Michael K. Gilson, Nei-Li Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/658289d67ad24135b29bba4a1384fb23
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spelling	oai:doaj.org-article:658289d67ad24135b29bba4a1384fb232021-12-02T16:49:55ZStructural insights into the gating of DNA passage by the topoisomerase II DNA-gate10.1038/s41467-018-05406-y2041-1723https://doaj.org/article/658289d67ad24135b29bba4a1384fb232018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05406-yhttps://doaj.org/toc/2041-1723Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-gate in an open conformation and discuss mechanistic implications.Shin-Fu ChenNan-Lan HuangJung-Hsin LinChyuan-Chuan WuYing-Ren WangYu-Jen YuMichael K. GilsonNei-Li ChanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shin-Fu Chen Nan-Lan Huang Jung-Hsin Lin Chyuan-Chuan Wu Ying-Ren Wang Yu-Jen Yu Michael K. Gilson Nei-Li Chan Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
description	Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-gate in an open conformation and discuss mechanistic implications.
format	article
author	Shin-Fu Chen Nan-Lan Huang Jung-Hsin Lin Chyuan-Chuan Wu Ying-Ren Wang Yu-Jen Yu Michael K. Gilson Nei-Li Chan
author_facet	Shin-Fu Chen Nan-Lan Huang Jung-Hsin Lin Chyuan-Chuan Wu Ying-Ren Wang Yu-Jen Yu Michael K. Gilson Nei-Li Chan
author_sort	Shin-Fu Chen
title	Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
title_short	Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
title_full	Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
title_fullStr	Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
title_full_unstemmed	Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
title_sort	structural insights into the gating of dna passage by the topoisomerase ii dna-gate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/658289d67ad24135b29bba4a1384fb23
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Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

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