Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis.

Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis.

<h4>Background</h4>Monocyte-derived macrophages critically perpetuate inflammatory responses after liver injury as a prerequisite for organ fibrosis. Experimental murine models identified an essential role for the CCR2-dependent infiltration of classical Gr1/Ly6C(+) monocytes in hepatic...

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Autores principales: Henning W Zimmermann, Sebastian Seidler, Jacob Nattermann, Nikolaus Gassler, Claus Hellerbrand, Alma Zernecke, Jens J W Tischendorf, Tom Luedde, Ralf Weiskirchen, Christian Trautwein, Frank Tacke
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/65833963b0494b00b25ef9a614a87593
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