Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling

The decorporation kinetics of internal radionuclide contamination is a long-term treatment raising modeling, planning, and managing problems, especially in the case of late intervention when the radiotoxic penetrated the deep compartments. The decorporation effectiveness of the highly radiotoxic <...

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Autores principales:	Victor Voicu, Marilena Jiquidi, Constantin Mircioiu, Roxana Sandulovici, Adrian Nicolescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radionuclides kinetics of decorporation compartmental vs. diffusional models square-root law Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/6583cf0996344b8888fdd33674fa218f
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spelling	oai:doaj.org-article:6583cf0996344b8888fdd33674fa218f2021-11-25T18:40:59ZExperimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling10.3390/pharmaceutics131118301999-4923https://doaj.org/article/6583cf0996344b8888fdd33674fa218f2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1830https://doaj.org/toc/1999-4923The decorporation kinetics of internal radionuclide contamination is a long-term treatment raising modeling, planning, and managing problems, especially in the case of late intervention when the radiotoxic penetrated the deep compartments. The decorporation effectiveness of the highly radiotoxic <sup>65</sup>ZnCl<sub>2</sub> by Zn-DTPA (dosed at 3.32 mg and 5 mg/0.25 mL/100 g body weight) was investigated in Wistar male rats over a ten-day period under various treatments (i.e., as a single dose before contamination; as a single dose before and 24 h after contamination; and as daily administrations for five consecutive days starting on day 12 after contamination). The radioactivity was measured using the whole-body counting method. Mono- and bi-compartmental decorporation kinetics models proved applicable in the case of a rapid intervention. It was found that a diffusion model of the radionuclide from tissues to blood better describes the decorporation kinetics after more than ten days post treatment, and the process has been mathematically modeled as a diffusion from an infinite reservoir to a semi-finite medium. The mathematical solution led to a square-root law for describing the <sup>65</sup>Zn decorporation. This law predicts a slower release than exponential or multiexponential equations, and could better explain the very long persistence of radionuclides in the living body. Splitting data and modeling in two steps allows a better understanding, description and prediction of the evolution of contamination, a separate approach to the treatment schemes of acute and chronic contamination.Victor VoicuMarilena JiquidiConstantin MircioiuRoxana SanduloviciAdrian NicolescuMDPI AGarticleradionuclideskinetics of decorporationcompartmental vs. diffusional modelssquare-root lawPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1830, p 1830 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radionuclides kinetics of decorporation compartmental vs. diffusional models square-root law Pharmacy and materia medica RS1-441
spellingShingle	radionuclides kinetics of decorporation compartmental vs. diffusional models square-root law Pharmacy and materia medica RS1-441 Victor Voicu Marilena Jiquidi Constantin Mircioiu Roxana Sandulovici Adrian Nicolescu Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
description	The decorporation kinetics of internal radionuclide contamination is a long-term treatment raising modeling, planning, and managing problems, especially in the case of late intervention when the radiotoxic penetrated the deep compartments. The decorporation effectiveness of the highly radiotoxic <sup>65</sup>ZnCl<sub>2</sub> by Zn-DTPA (dosed at 3.32 mg and 5 mg/0.25 mL/100 g body weight) was investigated in Wistar male rats over a ten-day period under various treatments (i.e., as a single dose before contamination; as a single dose before and 24 h after contamination; and as daily administrations for five consecutive days starting on day 12 after contamination). The radioactivity was measured using the whole-body counting method. Mono- and bi-compartmental decorporation kinetics models proved applicable in the case of a rapid intervention. It was found that a diffusion model of the radionuclide from tissues to blood better describes the decorporation kinetics after more than ten days post treatment, and the process has been mathematically modeled as a diffusion from an infinite reservoir to a semi-finite medium. The mathematical solution led to a square-root law for describing the <sup>65</sup>Zn decorporation. This law predicts a slower release than exponential or multiexponential equations, and could better explain the very long persistence of radionuclides in the living body. Splitting data and modeling in two steps allows a better understanding, description and prediction of the evolution of contamination, a separate approach to the treatment schemes of acute and chronic contamination.
format	article
author	Victor Voicu Marilena Jiquidi Constantin Mircioiu Roxana Sandulovici Adrian Nicolescu
author_facet	Victor Voicu Marilena Jiquidi Constantin Mircioiu Roxana Sandulovici Adrian Nicolescu
author_sort	Victor Voicu
title	Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
title_short	Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
title_full	Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
title_fullStr	Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
title_full_unstemmed	Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling
title_sort	experimental evaluation of <sup>65</sup>zn decorporation kinetics following rapid and delayed zn-dtpa interventions in rats. biphasic compartmental and square-root law mathematical modeling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6583cf0996344b8888fdd33674fa218f
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Experimental Evaluation of <sup>65</sup>Zn Decorporation Kinetics Following Rapid and Delayed Zn-DTPA Interventions in Rats. Biphasic Compartmental and Square-Root Law Mathematical Modeling

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