Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

Renae C Fernandez,1–3 Vivienne M Moore,1,3,4 Emer M Van Ryswyk,5 Tamara J Varcoe,1,2 Raymond J Rodgers,1,2 Wendy A March,1,3 Lisa J Moran,1,6 Jodie C Avery,1,2 R Doug McEvoy,5,7 Michael J Davies1,2 1The University of Adelaide, Robinson Research Institute, Adelaide, SA, Australia; 2The Univ...

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Autores principales:	Fernandez RC, Moore VM, Van Ryswyk EM, Varcoe TJ, Rodgers RJ, March WA, Moran LJ, Avery JC, McEvoy RD, Davies MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	polycystic ovary syndrome sleep sleep disturbance Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/658612ee34c646dcac6f995e1b8b1390
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spelling	oai:doaj.org-article:658612ee34c646dcac6f995e1b8b13902021-12-02T09:31:16ZSleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies1179-1608https://doaj.org/article/658612ee34c646dcac6f995e1b8b13902018-02-01T00:00:00Zhttps://www.dovepress.com/sleep-disturbances-in-women-with-polycystic-ovary-syndrome-prevalence--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Renae C Fernandez,1–3 Vivienne M Moore,1,3,4 Emer M Van Ryswyk,5 Tamara J Varcoe,1,2 Raymond J Rodgers,1,2 Wendy A March,1,3 Lisa J Moran,1,6 Jodie C Avery,1,2 R Doug McEvoy,5,7 Michael J Davies1,2 1The University of Adelaide, Robinson Research Institute, Adelaide, SA, Australia; 2The University of Adelaide, Adelaide Medical School, Adelaide, SA, Australia; 3The University of Adelaide, School of Public Health, Adelaide, SA, Australia; 4The University of Adelaide, Fay Gale Centre for Research on Gender, Adelaide, SA, Australia; 5Adelaide Institute for Sleep Health, Flinders Centre for Research Excellence, Flinders University of South Australia, Bedford Park, SA, Australia; 6Monash Centre for Health Research Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia; 7Adelaide Sleep Health, Southern Adelaide Local Health Network, Repatriation General Hospital, Daw Park, SA, Australia Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight. There are several, possibly bidirectional, pathways through which PCOS is associated with sleep disturbances. The pathophysiology of PCOS involves hyperandrogenemia, a form of insulin resistance unique to affected women, and possible changes in cortisol and melatonin secretion, arguably reflecting altered hypothalamic–pituitary–adrenal function. Psychological and behavioral pathways are also likely to play a role, as anxiety and depression, smoking, alcohol use and lack of physical activity are also common among women with PCOS, partly in response to the distressing symptoms they experience. The specific impact of sleep disturbances on the health of women with PCOS is not yet clear; however, both PCOS and sleep disturbances are associated with deterioration in cardiometabolic health in the longer term and increased risk of type 2 diabetes. Both immediate quality of life and longer-term health of women with PCOS are likely to benefit from diagnosis and management of sleep disorders as part of interdisciplinary health care. Keywords: polycystic ovary syndrome, sleep, sleep disturbance, hypothalamic-pituitary-adrenal, cardiometabolic healthFernandez RCMoore VMVan Ryswyk EMVarcoe TJRodgers RJMarch WAMoran LJAvery JCMcEvoy RDDavies MJDove Medical Pressarticlepolycystic ovary syndromesleepsleep disturbancePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 10, Pp 45-64 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	polycystic ovary syndrome sleep sleep disturbance Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	polycystic ovary syndrome sleep sleep disturbance Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Fernandez RC Moore VM Van Ryswyk EM Varcoe TJ Rodgers RJ March WA Moran LJ Avery JC McEvoy RD Davies MJ Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
description	Renae C Fernandez,1–3 Vivienne M Moore,1,3,4 Emer M Van Ryswyk,5 Tamara J Varcoe,1,2 Raymond J Rodgers,1,2 Wendy A March,1,3 Lisa J Moran,1,6 Jodie C Avery,1,2 R Doug McEvoy,5,7 Michael J Davies1,2 1The University of Adelaide, Robinson Research Institute, Adelaide, SA, Australia; 2The University of Adelaide, Adelaide Medical School, Adelaide, SA, Australia; 3The University of Adelaide, School of Public Health, Adelaide, SA, Australia; 4The University of Adelaide, Fay Gale Centre for Research on Gender, Adelaide, SA, Australia; 5Adelaide Institute for Sleep Health, Flinders Centre for Research Excellence, Flinders University of South Australia, Bedford Park, SA, Australia; 6Monash Centre for Health Research Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia; 7Adelaide Sleep Health, Southern Adelaide Local Health Network, Repatriation General Hospital, Daw Park, SA, Australia Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight. There are several, possibly bidirectional, pathways through which PCOS is associated with sleep disturbances. The pathophysiology of PCOS involves hyperandrogenemia, a form of insulin resistance unique to affected women, and possible changes in cortisol and melatonin secretion, arguably reflecting altered hypothalamic–pituitary–adrenal function. Psychological and behavioral pathways are also likely to play a role, as anxiety and depression, smoking, alcohol use and lack of physical activity are also common among women with PCOS, partly in response to the distressing symptoms they experience. The specific impact of sleep disturbances on the health of women with PCOS is not yet clear; however, both PCOS and sleep disturbances are associated with deterioration in cardiometabolic health in the longer term and increased risk of type 2 diabetes. Both immediate quality of life and longer-term health of women with PCOS are likely to benefit from diagnosis and management of sleep disorders as part of interdisciplinary health care. Keywords: polycystic ovary syndrome, sleep, sleep disturbance, hypothalamic-pituitary-adrenal, cardiometabolic health
format	article
author	Fernandez RC Moore VM Van Ryswyk EM Varcoe TJ Rodgers RJ March WA Moran LJ Avery JC McEvoy RD Davies MJ
author_facet	Fernandez RC Moore VM Van Ryswyk EM Varcoe TJ Rodgers RJ March WA Moran LJ Avery JC McEvoy RD Davies MJ
author_sort	Fernandez RC
title	Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_short	Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_full	Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_fullStr	Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_full_unstemmed	Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_sort	sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/658612ee34c646dcac6f995e1b8b1390
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Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

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