Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial

Abstract Precursors of neurotransmitters are increasingly often investigated as potential, easily-accessible methods of neuromodulation. However, the amino-acid glutamine, precursor to the brain’s main excitatory and inhibitory neurotransmitters glutamate and GABA, remains notably little investigate...

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Autores principales:	Bryant J. Jongkees, Maarten A. Immink, Lorenza S. Colzato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6587c8bebda2453792fb843391800563
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spelling	oai:doaj.org-article:6587c8bebda2453792fb8433918005632021-12-02T11:40:45ZInfluences of glutamine administration on response selection and sequence learning: a randomized-controlled trial10.1038/s41598-017-02957-w2045-2322https://doaj.org/article/6587c8bebda2453792fb8433918005632017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02957-whttps://doaj.org/toc/2045-2322Abstract Precursors of neurotransmitters are increasingly often investigated as potential, easily-accessible methods of neuromodulation. However, the amino-acid glutamine, precursor to the brain’s main excitatory and inhibitory neurotransmitters glutamate and GABA, remains notably little investigated. The current double-blind, randomized, placebo-controlled study provides first evidence 2.0 g glutamine administration in healthy adults affects response selection but not motor sequence learning in a serial reaction time task. Specifically, glutamine increased response selection errors when the current target response required a different hand than the directly preceding target response, which might indicate enhanced cortical excitability via a presumed increase in glutamate levels. These results suggest glutamine can alter cortical excitability but, despite the critical roles of glutamate and GABA in motor learning, at its current dose glutamine does not affect sequence learning.Bryant J. JongkeesMaarten A. ImminkLorenza S. ColzatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryant J. Jongkees Maarten A. Immink Lorenza S. Colzato Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
description	Abstract Precursors of neurotransmitters are increasingly often investigated as potential, easily-accessible methods of neuromodulation. However, the amino-acid glutamine, precursor to the brain’s main excitatory and inhibitory neurotransmitters glutamate and GABA, remains notably little investigated. The current double-blind, randomized, placebo-controlled study provides first evidence 2.0 g glutamine administration in healthy adults affects response selection but not motor sequence learning in a serial reaction time task. Specifically, glutamine increased response selection errors when the current target response required a different hand than the directly preceding target response, which might indicate enhanced cortical excitability via a presumed increase in glutamate levels. These results suggest glutamine can alter cortical excitability but, despite the critical roles of glutamate and GABA in motor learning, at its current dose glutamine does not affect sequence learning.
format	article
author	Bryant J. Jongkees Maarten A. Immink Lorenza S. Colzato
author_facet	Bryant J. Jongkees Maarten A. Immink Lorenza S. Colzato
author_sort	Bryant J. Jongkees
title	Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
title_short	Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
title_full	Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
title_fullStr	Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
title_full_unstemmed	Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
title_sort	influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6587c8bebda2453792fb843391800563
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Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial

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