Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed bas...

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Autor principal:	Khaldoon Thanoon Al-Abachi
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Revinter Publicações Ltda. 2021
Materias:	irritable bowel syndrome celiac disease anti-ttg antibodies duodenal biopsy Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/658f8fd1055347cc8d13140120b68f59
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spelling	oai:doaj.org-article:658f8fd1055347cc8d13140120b68f592021-11-18T23:52:51ZScreening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria2237-93632317-642310.1055/s-0041-1736645https://doaj.org/article/658f8fd1055347cc8d13140120b68f592021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736645https://doaj.org/toc/2237-9363https://doaj.org/toc/2317-6423Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria. Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD. Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation. Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.Khaldoon Thanoon Al-AbachiThieme Revinter Publicações Ltda.articleirritable bowel syndromeceliac diseaseanti-ttg antibodiesduodenal biopsyDiseases of the digestive system. GastroenterologyRC799-869ENJournal of Coloproctology (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	irritable bowel syndrome celiac disease anti-ttg antibodies duodenal biopsy Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	irritable bowel syndrome celiac disease anti-ttg antibodies duodenal biopsy Diseases of the digestive system. Gastroenterology RC799-869 Khaldoon Thanoon Al-Abachi Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
description	Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria. Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD. Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation. Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.
format	article
author	Khaldoon Thanoon Al-Abachi
author_facet	Khaldoon Thanoon Al-Abachi
author_sort	Khaldoon Thanoon Al-Abachi
title	Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
title_short	Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
title_full	Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
title_fullStr	Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
title_full_unstemmed	Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
title_sort	screening for celiac disease in patients with irritable bowel syndrome fulfilling rome iii criteria
publisher	Thieme Revinter Publicações Ltda.
publishDate	2021
url	https://doaj.org/article/658f8fd1055347cc8d13140120b68f59
work_keys_str_mv	AT khaldoonthanoonalabachi screeningforceliacdiseaseinpatientswithirritablebowelsyndromefulfillingromeiiicriteria
_version_	1718420672030441472

Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

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